Gateway on Pesticide Hazards and Safe Pest Management

Beyond Pesticides offers resources below to evaluate the health and ecological effects of specific chemical exposure from ACTIVE INGREDIENTS in pesticide products, as well as regulatory information and supporting scientific documents. Because various pesticide products can contain more than one active ingredient, it is important to READ the LABEL to determine chemical components.

With 192 different active ingredients and counting, it is essential to establish the connection between the use of these chemicals and their respective hazards.

View the step-by-step guide on how to search for the active ingredient(s) in pesticide products below:

1. Go to U.S. EPA's Pesticide Product and Label System and enter the product name. The generic product name may vary.
   
2. After searching, click on the chemical ingredients tab or the link for the most recent label to find Active Ingredients.
                Chemical List                                            Label List 
   
   If one selects the chemical ingredients tab, skip to Step 4 . If not, proceed to step number 3
   
   
3. To find the active ingredient(s) on the label, search for the page in the document containing the date of registration. Usually, the active ingredients section occurs within the first few pages of the label document.
   
   
4. Return to the Beyond Pesticides Gateway and search for the active ingredient name in the yellow box to the right or from the list below. 
   
   

Updates from the Daily News Blog

Study Finds Aquatic Ecosystem Collapse with Neonicotinoid Exposure, Threatening Biodiversity
May 6, 2025

Sampling Finds Pesticides Throughout Environment with Toxic Mixtures from Agricultural Use
March 28, 2025

Deadly Poisoning of Dozens of Children in South Africa Highlights Global Pesticide Threat to Human Life  
December 19, 2024

Investigative Report Finds Canada’s Reversal of Neonicotinoid Ban Influenced by Bayer/Monsanto
December 18, 2024

Review Cites Memory and Learning Impairments; Children, Workers, and Nontarget Organisms at Risk
December 12, 2024

Evaluation of EPA Safety Data on Neonicotinoid Insecticides Identifies Scientific Failures
November 5, 2024

Enhanced Bioavailability and Contamination of Neonicotinoid Pesticides Linked to Microplastics in Soil
July 23, 2024

Literature Review Analyzes Pesticide Sensitivity in Bee Species on a Molecular Level
June 21, 2024

Bayer’s Use of EU-Forbidden Pesticides Ignites Protest in South Africa 
September 19, 2023

Study Connects Neonicotinoids to Liver Damage Ignored by EPA
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Thiacloprid

General Information

• Product Names:

  Calypso (Bayer)

• Chemical Class: Chloronicotinoid Insecticide
• Uses: On the agricultural crops cotton and pome fruits for control of a variety of sucking insects. The primary target pests for thiacloprid on cotton are aphids and whiteflies; Psylla, codling moth and plum Curculio are the primary pests on pome fruits.
• Alternatives: Organic agriculture

Health and Environmental Effects

• Cancer: Likely (39)
• Endocrine Disruption: Not documented
• Reproductive Effects: Not documented
• Neurotoxicity: Yes (39)
• Kidney/Liver Damage: Yes (25)
• Sensitizer/ Irritant: Not documented
• Birth/Developmental: Yes (39)
• Detected in Groundwater: Not documented
• Potential Leacher: Yes (39)
• Toxic to Birds: Not documented
• Toxic to Fish/Aquatic Organisms: Not documented
• Toxic to Bees: Not documented

Residential Uses as Found in the ManageSafe™ Database

• Bed Bugs

Additional Information

• Regulatory Status:
  • EPA Conditional Registration Issued 9/2006
• Supporting information:
  • PAN Pesticides Database: Thiacloprid (Pesticide Action Network)
• Studies:
  • Effects of neonicotinoid pesticide exposure on human health: a systematic review. Cimino AM, Boyles AL, Thayer KA, Perry MJ. 2017. Environ Health Perspect. 125:155–162
  • Direct pesticide exposure of insects in nature conservation areas in Germany. Brühl, C.A., Bakanov, N., Köthe, S., Eichler, L., Sorg, M., Hörren, T., Mühlethaler, R., Meinel, G. and Lehmann, G.U. Scientific reports, 11(1), pp.1-10.
  • Neonicotinoids: Still present in farmland birds despite their ban. Fuentes, E., Gaffard, A., Rodrigues, A., Millet, M., Bretagnolle, V., Moreau, J. and Monceau, K., 2023. Chemosphere, 321, p.138091.
  • Prevalence of neonicotinoid insecticides in paired private-well tap water and human urine samples in a region of intense agriculture overlying vulnerable aquifers in eastern Iowa. Thompson, D.A., Kolpin, D.W., Hladik, M.L., Lehmler, H.J., Meppelink, S.M., Poch, M.C., Vargo, J.D., Soupene, V.A., Irfan, N.M., Robinson, M. and Kannan, K., 2023. Chemosphere, 319, p.137904.
  • Infantile Internal and External Exposure to Neonicotinoid Insecticides: A Comparison of Levels across Various Sources. Zhang, H., Wang, Y., Zhu, H., Lu, S., Wang, Y., Xue, J., Zhang, T., Kannan, K. and Sun, H., 2023. Environmental Science & Technology, 57(13), pp.5358-5367.
  • Organic farming reduces pesticide load in a bird of prey. Fuentes, E. et al. (2024) Organic farming reduces pesticide load in a bird of prey, Science of The Total Environment. Available at: https://www.sciencedirect.com/science/article/pii/S0048969724029255.
  • The molecular determinants of pesticide sensitivity in bee pollinators. Bass, C. et al (2024) The molecular determinants of pesticide sensitivity in bee pollinators, Science of The Total Environment. Available at: https://www.sciencedirect.com/science/article/pii/S0048969724003097.
  • Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin. Brandt, A. et al. (2017) Immunosuppression in honeybee queens by the neonicotinoids Thiacloprid and Clothianidin, Scientific Reports. Available at: https://pubmed.ncbi.nlm.nih.gov/28680118/.
  • Interactions of traditional and biodegradable microplastics with neonicotinoid pesticides. Wang, K. et al. (2024) Interactions of traditional and biodegradable microplastics with neonicotinoid pesticides, The Science of The Total Environment. Available at: https://pubmed.ncbi.nlm.nih.gov/38972406/.
  • Neonicotinoid pesticides: evidence of developmental neurotoxicity from regulatory rodent studies. Sass, J.B., Donley, N. and Freese, W. (2024) Neonicotinoid pesticides: evidence of developmental neurotoxicity from regulatory rodent studies, Frontiers in Toxicology. Available at: https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2024.1438890/full.
  • Neuroprotective effect of piracetam-loaded magnetic chitosan nanoparticles against thiacloprid-induced neurotoxicity in albino rats. Abomosallam, M., Hendam, B.M., Abdallah, A.A. et al. Neuroprotective effect of piracetam-loaded magnetic chitosan nanoparticles against thiacloprid-induced neurotoxicity in albino rats. Inflammopharmacol 31, 943–965 (2023). https://doi.org/10.1007/s10787-023-01151-x
  • Pesticide-Induced Inflammation at a Glance. Lopes-Ferreira, M. et al. (2023) ‘Pesticide-induced inflammation at a glance’, Toxics, 11(11), p. 896. doi:10.3390/toxics11110896.
  • Current-use pesticides in vegetation, topsoil and water reveal contaminated landscapes of the Upper Rhine Valley, Germany. Mauser, K.M., Wolfram, J., Spaak, J.W. et al. Current-use pesticides in vegetation, topsoil and water reveal contaminated landscapes of the Upper Rhine Valley, Germany. Commun Earth Environ 6, 166 (2025). https://doi.org/10.1038/s43247-025-02118-2
  • Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor. Zhang, C., Schilirò, T., Gea, M., Bianchi, S., Spinello, A., Magistrato, A., Gilardi, G., & Di Nardo, G. (2020). Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor. International journal of environmental research and public health, 17(16), 5664. https://doi.org/10.3390/ijerph17165664
  • Widespread Pesticide Distribution in the European Atmosphere Questions their Degradability in Air. Mayer, L., Degrendele, C., Šenk, P., Kohoutek, J., Přibylová, P., Kukučka, P., Melymuk, L., Durand, A., Ravier, S., Alastuey, A., Baker, A. R., Baltensperger, U., Baumann-Stanzer, K., Biermann, T., Bohlin-Nizzetto, P., Ceburnis, D., Conil, S., Couret, C., Degórska, A., Diapouli, E., … Lammel, G. (2024). Widespread Pesticide Distribution in the European Atmosphere Questions their Degradability in Air. Environmental science & technology, 58(7), 3342–3352. Advance online publication. https://doi.org/10.1021/acs.est.3c08488
  • Immunosuppression response to the neonicotinoid insecticide thiacloprid in females and males of the red mason bee Osmia bicornis L.. Brandt, A., Hohnheiser, B., Sgolastra, F. et al. Immunosuppression response to the neonicotinoid insecticide thiacloprid in females and males of the red mason bee Osmia bicornis L.. Sci Rep 10, 4670 (2020). https://doi.org/10.1038/s41598-020-61445-w
  • Do novel insecticides pose a threat to beneficial insects?. Siviter Harry and Muth Felicity 2020 Do novel insecticides pose a threat to beneficial insects?Proc. R. Soc. B.28720201265 http://doi.org/10.1098/rspb.2020.1265
  • Acute toxicity of 6 neonicotinoid insecticides to freshwater invertebrates. Raby, M., Nowierski, M., Perlov, D., Zhao, X., Hao, C., Poirier, D. G., & Sibley, P. K. (2018). Acute toxicity of 6 neonicotinoid insecticides to freshwater invertebrates. Environmental toxicology and chemistry, 37(5), 1430–1445. https://doi.org/10.1002/etc.4088
  • Neonicotinoids and fertilizers jointly structure naturally assembled freshwater macroinvertebrate communities. Barmentlo, S. H., Schrama, M., van Bodegom, P. M., de Snoo, G. R., Musters, C. J. M., & Vijver, M. G. (2019). Neonicotinoids and fertilizers jointly structure naturally assembled freshwater macroinvertebrate communities. The Science of the total environment, 691, 36–44. https://doi.org/10.1016/j.scitotenv.2019.07.110
  • Networks in Aquatic Communities Collapse Upon Neonicotinoid-Induced Stress. Barmentlo, S. et al. (2025) Networks in Aquatic Communities Collapse Upon Neonicotinoid-Induced Stress, Ecology Letters. Available at: https://onlinelibrary.wiley.com/doi/10.1111/ele.70121.