Gateway on Pesticide Hazards and Safe Pest Management

Beyond Pesticides offers resources below to evaluate the health and ecological effects of specific chemical exposure from ACTIVE INGREDIENTS in pesticide products, as well as regulatory information and supporting scientific documents. Because various pesticide products can contain more than one active ingredient, it is important to READ the LABEL to determine chemical components.

With 192 different active ingredients and counting, it is essential to establish the connection between the use of these chemicals and their respective hazards.

View the step-by-step guide on how to search for the active ingredient(s) in pesticide products below:

1. Go to U.S. EPA's Pesticide Product and Label System and enter the product name. The generic product name may vary.
   
2. After searching, click on the chemical ingredients tab or the link for the most recent label to find Active Ingredients.
                Chemical List                                            Label List 
   
   If one selects the chemical ingredients tab, skip to Step 4 . If not, proceed to step number 3
   
   
3. To find the active ingredient(s) on the label, search for the page in the document containing the date of registration. Usually, the active ingredients section occurs within the first few pages of the label document.
   
   
4. Return to the Beyond Pesticides Gateway and search for the active ingredient name in the yellow box to the right or from the list below. 
   
   

Pyriproxyfen

General Information

• Product Names:

  Archer Insct Growth Regulator (Sygenta)
  Country Vet Roach Embargo with Growth Inhibitor (FMC) formulated with Esfenvalerate
  Nylar (McGlaughin Gomrly King)
  Seper Nylar E.C. (Wellmark)
  Sumilarv (Sumitomo)
  Unicorn IGR (Phaeton)
  I.G. Regulator (Control Solutions)
  Knack (Valent)
  Distance Insect Growth Regulator (Valent)
  Esteem Insect Growth Regulator (Valent)
   Proxy (Makhteshim)

• Chemical Class: Unclassified
• Uses: Agriculture, structural pest control
• Alternatives: Organic agriculture, Organic lawn care
• Beyond Pesticides rating: Toxic

Health and Environmental Effects

• Cancer: Insufficiently Studied
• Endocrine Disruption: Likely (1, 2)
• Reproductive Effects: Likely (3, 4)
• Neurotoxicity: Possible (5)
• Kidney/Liver Damage: Yes (6)
• Sensitizer/ Irritant: Not Likely
• Birth/Developmental: Likely (4, 5)
• Detected in Groundwater: Low (7)
• Potential Leacher: Parent = Slight; Metabolite = Yes (8)
• Toxic to Birds: Possible (9)
• Toxic to Fish/Aquatic Organisms: Yes (10, 2)
• Toxic to Bees: Yes (11, 12, 13)

Residential Uses as Found in the ManageSafe™ Database

• Fleas
• Ants
• Cockroaches
• Carpet Beetle
• Fire Ants

Additional Information

• Supporting information:
  • PAN Pesticides Database: Pyriproxyfen
• Studies [compiled from the Pesticide-Induced Diseases Database]
  • Fate of pyriproxyfen in soils and plants. Devillers, J., 2020. Toxics, 8(1), p.20.
  • Determination by chromatography and cytotoxotoxic and oxidative effects of pyriproxyfen and pyridalyl. de Oliveira, M.D.D.A., de Almeida, P.M., Martins, F.A., Cavalcante, A.A.D.C.M., dos Santos, T.D.J.A., Feitosa, C.M., Rai, M., dos Reis, A.C. and da Costa Júnior, J.S., 2019. Chemosphere, 224, pp.398-406.
  • The enantioselective environmental behavior and toxicological effects of pyriproxyfen in soil. Liu, H., Yi, X., Bi, J., Wang, P., Liu, D. and Zhou, Z., 2019. Journal of hazardous materials, 365, pp.97-106.
  • The pyriproxyfen metabolite, 4′–OH–PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. Vancamp, P., Spirhanzlova, P., Sébillot, A., Butruille, L., Gothié, J.D., Le Mével, S., Leemans, M., Wejaphikul, K., Meima, M., Mughal, B.B. and Roques, P. Environmental Pollution, 285, p.117654.
  • The potential endocrine disruption of pesticide transformation products (TPs): The blind spot of pesticide risk assessment. Ji, C., Song, Q., Chen, Y., Zhou, Z., Wang, P., Liu, J., Sun, Z., & Zhao, M. (2020). The potential endocrine disruption of pesticide transformation products (TPs): The blind spot of pesticide risk assessment. Environment international, 137, 105490. https://doi.org/10.1016/j.envint.2020.105490