Gateway on Pesticide Hazards and Safe Pest Management

Chlorpyrifos

General Information

Fact Sheet: Chlorpyrifos.pdf
Product Names:
Chemsico roach control (Chemiso)
Pyrinex mole cricket bait (Micro-Flo)
Dursban (Dow AgroSciences)
Lorsban (Dow AgroSciences)
Ortho Ant Stop (Solaris Group), formulated with Calcium silicate, Aromatic petroleum distillates
Ortho Dursban Lawn & Garden Insect Control (Solaris Group), formulated with Calcium silicate
Bonide Termite & Carpenter Ant Dust (Bonide Products)
Raid Ant Bait (SC Johnson)
Hot Shot Maxattrax Roach Bait (Spectrum Brands)
Chemical Class: Organophosphate insecticide
Uses: food and feed crops, golf courses, as a non-structural wood treatment, and as an adult mosquitocide
Alternatives: Agriculture, Nonresidential buildings
Beyond Pesticides rating: Toxic

Health and Environmental Effects

Cancer: Not documented
Endocrine Disruption: Yes (30)
Reproductive Effects: Yes (6)
Neurotoxicity: Yes (8)
Kidney/Liver Damage: Yes (17)
Sensitizer/ Irritant: Yes (4)
Birth/Developmental: Yes (6)
Detected in Groundwater: Yes (6)
Potential Leacher: Yes (6)
Toxic to Birds: Yes (8)
Toxic to Fish/Aquatic Organisms: Yes (8, 111)
Toxic to Bees: Yes (8)

Residential Uses as Found in the ManageSafe™ Database

Additional Information

Regulatory Status:
Supporting information:
- Daily News Blog entries (Beyond Pesticides)
- Widely Used Pesticide in Food Production Damages Children’s Brains (Beyond Pesticides, 2017)
- Asthma, Children and Pesticides (Beyond Pesticides)
- The Low Down on Dursban (Beyond Pesticides)
- Alternatives to Using Chlorpyrifos (Beyond Pesticides)
- Safer Choice (Beyond Pesticides)
- NCAP Chlorpyrifos Factsheet (Northwest Coalition for Alternatives to Pesticides)
- Extoxnet Chlorpyrifos Factsheet (Extension Toxicology Network)
- PAN Pesticides Database:Chlorpyrifos (Pesticide Action Network)
Studies:
- Effects of chlorpyrifos on the crustacean Litopenaeus vannamei Duarte-Restrepo, E., Jaramillo-Colorado, B.E. and Duarte-Jaramillo, L., 2020. PloS one, 15(4), p.e0231310.
- Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Rauh VA, Perera FP, Horton MK, et al. 2012. Proc Natl Acad Sci U S A. 109(20):7871-6.
- Chlorpyrifos exposure and urban residential environment characteristics as determinants of early childhood neurodevelopment. Lovasi GS, Quinn JW, Rauh VA, et al. 2011. Am J Public Health. 101(1):63-70.
- Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Rauh VA, Garfinkel R, Perera FP, et al. 2006. Pediatrics.118(6):e1845-59.
- Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero. Haviland, J. A., Butz, D. E., Porter, W.P. 2009. Reproductive Toxicology. 29(1):74-79
- Top 15 Farmworker Poison
- 7-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide. Rauh V, Arunajadai S, Horton M, Perera F, Hoepner L, Barr DB, et al. 2011. Environ Health Perspect. doi:10.1289/ehp.1003160
- A pilot study of pesticides and PCBs in the breast milk of women residing in urban and agricultural communities of California.. Weldon RH, Barr DB, Trujillo C, et al. 2011. J Environ Monit. 13(11):3136-44.
- Acute exposure to chlorpyrifos caused NADPH oxidase mediated oxidative stress and neurotoxicity in a striatal cell model of Huntington’s disease. Dominah, G.A., McMinimy, R.A., Kallon, S. and Kwakye, G.F., 2017. Neurotoxicology, 60, pp.54-69.
- ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy. Grabovska S, Salyha Y. 2015. Arh Hig Rada Toksikol. 66(2):121-7
- Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice.. Peris-Sampedro F, Cabré M, Basaure P, Reverte I, et al. 2015. Environ Res. 142:169-76
- Agreement of pesticide biomarkers between morning void and 24-h urine samples from farmers and their children. Scher, D. et al. 2007, J. Exposure Science and Environmental Epidemiology; 17, 350–357
- Assessment of genetic effects and pesticide exposure of farmers in NW Greece. Moshou, H., Karakitsou, A., Yfanti, F., Hela, D., Vlastos, D., Paschalidou, A.K., Kassomenos, P. and Petrou, I., 2020. Environmental Research, p.109558.
- Anthropogenic stressors impact fish sensory development and survival via thyroid disruption. Besson, M., Feeney, W.E., Moniz, I., François, L., Brooker, R.M., Holzer, G., Metian, M., Roux, N., Laudet, V. and Lecchini, D., 2020. Nature communications, 11(1), pp.1-10.
- Potential short-term neurobehavioral alterations in children associated with a peak pesticide spray season: The Mother’s Day flower harvest in Ecuador. Suarez-Lopez, J.R., Checkoway, H., Jacobs Jr, D.R., Al-Delaimy, W.K. and Gahagan, S., 2017. Neurotoxicology, 60, pp.125-133.
- Assessing Field‐Scale Risks of Foliar Insecticide Applications to Monarch Butterfly (Danaus plexippus) Larvae. Krishnan, N., Zhang, Y., Bidne, K.G., Hellmich, R.L., Coats, J.R. and Bradbury, S.P., 2020. Environmental Toxicology and Chemistry, 39(4), pp.923-941.
- Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study. von Ehrenstein, et al. 2019. BMJ 2019;364:l962
- Biomonitoring of persons exposed to insecticides used in residences. Krieger, R.I., Bernard, C.E., Dinoff, T.M., Ross J.H. and Williams R.L. 2001. Ann Occup Hyg, 45 (suppl 1): S143-S153. doi: 10.1093/annhyg/45.suppl_1.S143
- Blood α-synuclein in agricultural pesticide handlers in central Washington State.. Searles Nielsen S, Checkoway H, Zhang J, et al. 2015. Environ Res.136:75-81.
- Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Rauh, V. A., F. P. Perera, M. K. Horton, R. M. Whyatt, et al. 2012. PNAS.109 (20): 7871-6.
- Cancer Incidence Among Pesticide Applicators Exposed to Chlorpyrifos in the Agricultural Health Study. Lee WJ, et al. 2004. J Natl Cancer Inst. 96(23):1781-9.