Gateway on Pesticide Hazards and Safe Pest Management
Beyond Pesticides offers resources below to evaluate the health and ecological effects of specific chemical exposure from ACTIVE INGREDIENTS in pesticide products, as well as regulatory information and supporting scientific documents. Because various pesticide products can contain more than one active ingredient, it is important to READ the LABEL to determine chemical components.
With 192 different active ingredients and counting, it is essential to establish the connection between the use of these chemicals and their respective hazards.
View the step-by-step guide on how to search for the active ingredient(s) in pesticide products below:
- Go to U.S. EPA's Pesticide Product and Label System and enter the product name. The generic product name may vary.
- After searching, click on the chemical ingredients tab or the link for the most recent label to find Active Ingredients.
Chemical List Label List
If one selects the chemical ingredients tab, skip to Step 4 . If not, proceed to step number 3
- To find the active ingredient(s) on the label, search for the page in the document containing the date of registration. Usually, the active ingredients section occurs within the first few pages of the label document.
- Return to the Beyond Pesticides Gateway and search for the active ingredient name in the yellow box to the right or from the list below.
- Product Names:
- Chemical Class: Nitroguanidine (subgroup of nicotinoids) insecticide
- Uses: Agriculture
- Alternatives: Organic Agriculture
- Beyond Pesticides rating: Toxic
Health and Environmental Effects
- Cancer: Not documented
- Endocrine Disruption: Not documented
- Reproductive Effects: Not documented
- Neurotoxicity: Yes (39)
- Kidney/Liver Damage: Not documented
- Sensitizer/ Irritant: Not documented
- Birth/Developmental: Not documented
- Detected in Groundwater: Not documented
- Potential Leacher: Not documented
- Toxic to Birds: Yes (79)
- Toxic to Fish/Aquatic Organisms: Yes (39)
- Toxic to Bees: Yes (39)
Residential Uses as Found in the ManageSafe™ Database
- Regulatory Status:
- Supporting information:
- Daily News Blog
- Pesticides and Pollinators: Chemicals Implicated in Colony
- EFSA risk assessments of three neonicotinoids – clothianidin, imidacloprid and thiamethoxam
- EU Commission: Neonicotinoids
- EFSA consultation for thiamethoxam (2016)
- Poisoned Waterways (Beyond Pesticides, 2017)
- Net Loss—Economic Efficacy And Costs Of Neonicotinoid Insecticides Used As Seed Coatings: Updates From The United States And Europe (Center for Food Safety, 2016)
- Heavy Costs: Weighing the Value of Neonicotinoid Insecticides in Agriculture (Center for Food Safety, 2014)
- The Xerces Society - Neonicotinoids and Bees
- The neonicotinoid insecticide clothianidin adversely affects immune signaling in a human cell line. Di Prisco G, Iannaccone M, Ianniello F, et al. 2017. Sci Rep. 7(1):13446.
- Effects of neonicotinoid pesticide exposure on human health: a systematic review. Cimino AM, Boyles AL, Thayer KA, Perry MJ. 2017. Environ Health Perspect. 125:155–162
- Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin. Brandt A, Grikscheit K, Siede R, et al. 2017. Sci Rep. 7(1):4673.
- Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees. Di Prisco G, Cavaliere V, Annoscia D, et al. 2013. Proc Natl Acad Sci U S A. 110(46):18466-71
- First national-scale reconnaissance of neonicotinoid insecticides in streams across the U.S.A. Hladik, M.L. and Kolpin, D.W., 2016. Environ. Chem., v. 13, pp. 12-20.
- Pesticides are the dominant stressors for vulnerable insects in lowland streams. Liess, M., Liebmann, L., Vormeier, P., Weisner, O., Altenburger, R., Borchardt, D., Brack, W., Chatzinotas, A., Escher, B., Foit, K. and Gunold, R. Water Research, 201, p.117262.
- Neonicotinoid insecticides promote breast cancer progression via G protein-coupled estrogen receptor: In vivo, in vitro and in silico studies. Li, X., He, S., Xiao, H., He, T.T., Zhang, J.D., Luo, Z.R., Ma, J.Z., Yin, Y.L., Luo, L. and Cao, L.Y., 2022. Environment International, 170, p.107568.