Gateway on Pesticide Hazards and Safe Pest Management

Updates from the Daily News Blog

Endangered Species Likely To Be Hard Hit by Neonicotinoid Insecticides, EPA Finds
September 8, 2021

Death of as Many as 107,000 Bumblebees from Neonicotinoid Insecticides Studied
July 16, 2021

Pesticide Contamination in Waterways Raises New Alarm for Aquatic Life, Citing Poor Regulation
June 23, 2021

Maine Bans Consumer Use of Neonicotinoid Insecticides, with Some Exceptions
June 18, 2021

Pesticide Pollution in Recreational Lakes Documented
April 16, 2021

Farmland Birds’ Exposure to Neonicotinoid-Treated Seeds (during Winter Seeding) Confirmed by Blood Plasma Tests
April 16, 2020

Pesticide-Intensive Agriculture Contributes to Severe Monarch Butterfly Decline through Milkweed Contamination
July 8, 2019

Neonicotinoid Insecticide Residues in Food and Water on the Rise, According to USDA Data
May 2, 2019

Take Action: Saving America’s Pollinators Act Reintroduced in Congress
March 4, 2019

Settlement Bans Some Bee-Toxic Pesticides, Requires Public Comment Period on Testing All Pesticide Product Ingredients and Regulating Pesticide-Treated Seeds
January 4, 2019

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Clothianidin

General Information

• Product Names:

  Aloft (Arysta) formulated with Bifenthrin
  Arena (Valent)
  Darlex (Valent)
  Poncho (Bayer)
  Prosper (Bayer) formulated with Penflufen
  Sepresto (Bayer) formulated with imidacloprid
  Three-way (Bayer) formulated with Metalaxyl and ipconazole
  Titan (Bayer) formulated with Thiram, Carboxin and Metalaxyl

• Chemical Class: Nitroguanidine (subgroup of nicotinoids) insecticide
• Uses: Agriculture
• Alternatives: Organic Agriculture
• Beyond Pesticides rating: Toxic

Health and Environmental Effects

• Cancer: Not documented
• Endocrine Disruption: Not documented
• Reproductive Effects: Not documented
• Neurotoxicity: Yes (39)
• Kidney/Liver Damage: Not documented
• Sensitizer/ Irritant: Not documented
• Birth/Developmental: Not documented
• Detected in Groundwater: Not documented
• Potential Leacher: Not documented
• Toxic to Birds: Yes (79)
• Toxic to Fish/Aquatic Organisms: Yes (39)
• Toxic to Bees: Yes (39)

Residential Uses as Found in the ManageSafe™ Database

• Ants
• Chinch Bugs
• Cockroaches
• Grubs
• Clover
• Fire Ants

Additional Information

• Regulatory Status:
  • Clothianidin Registration Review
  • EPA Actions on Pollinators
  • Beyond Pesticides' Non-Pollinator Neonictinoid Assesment comments (4/2018)
  • Beyond Pesticides' EPA registration review bee risk assessmnet comments (7/2017)
  • Clothianidin EPA Petition and Response (2012)
  • EPA Factsheet (2013)
• Supporting information:
  • Daily News Blog
  • Pesticides and Pollinators: Chemicals Implicated in Colony 
  • EFSA risk assessments of three neonicotinoids – clothianidin, imidacloprid and thiamethoxam
  • EU Commission: Neonicotinoids
  • EFSA consultation for thiamethoxam (2016)
  • Poisoned Waterways (Beyond Pesticides, 2017)
  • Net Loss—Economic Efficacy And Costs Of Neonicotinoid Insecticides Used As Seed Coatings: Updates From The United States And Europe (Center for Food Safety, 2016)
  • Heavy Costs: Weighing the Value of Neonicotinoid Insecticides in Agriculture (Center for Food Safety, 2014)
  • The Xerces Society - Neonicotinoids and Bees
• Studies:
  • The neonicotinoid insecticide clothianidin adversely affects immune signaling in a human cell line. Di Prisco G, Iannaccone M, Ianniello F, et al. 2017. Sci Rep. 7(1):13446.
  • Effects of neonicotinoid pesticide exposure on human health: a systematic review. Cimino AM, Boyles AL, Thayer KA, Perry MJ. 2017. Environ Health Perspect. 125:155–162
  • Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin. Brandt A, Grikscheit K, Siede R, et al. 2017. Sci Rep. 7(1):4673.
  • Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees. Di Prisco G, Cavaliere V, Annoscia D, et al. 2013. Proc Natl Acad Sci U S A. 110(46):18466-71
  • First national-scale reconnaissance of neonicotinoid insecticides in streams across the U.S.A. Hladik, M.L. and Kolpin, D.W., 2016. Environ. Chem., v. 13, pp. 12-20.