.png)
Gateway test
Rotenone
General Information
- Fact Sheet: Rotenone.pdf
- Product Names:
- Chemical Class: Botanical insecticde
- Uses: Applied directly to water to manage fish populations in lakes, ponds, reservoirs, rivers, streams, and in aquaculture.
- Beyond Pesticides rating: Toxic
Health and Environmental Effects
- Cancer: Not documented
- Endocrine Disruption: Not documented
- Reproductive Effects: Not documented
- Neurotoxicity: Not documented
- Kidney/Liver Damage: Yes (1)
- Sensitizer/ Irritant: Yes (1)
- Birth/Developmental: Not documented
- Detected in Groundwater: Not documented
- Potential Leacher: Not documented
- Toxic to Birds: Not documented
- Toxic to Fish/Aquatic Organisms: Yes (1)
- Toxic to Bees: Yes (2)
Additional Information
- Regulatory Status:
- Supporting information:
- Extoxnet Rotenone Factsheet (Extension Toxicology Network)
- PAN Pesticides Database:Rotenone (Pesticide Action Network)
- PAN UK Rotenone Factsheet (Pesticide Action Network UK)
- Scorecard Rotenone Factsheet (The Pollution Information Site)
- Studies [compiled from the Pesticide-Induced Diseases Database]
- Rotenone Linked to Parkinson's Disease (Beyond Pesticides Daily News Archive)
- Cerebellar neurochemical and histopathological changes in rat model of Parkinson's disease induced by intrastriatal injection of rotenone.. Khadrawy YA, Mourad IM, Mohammed HS, et al. 2017. Gen Physiol Biophys. 36(1):99-108.
- Chronic exposure to rotenone, a dopaminergic toxin, results in peripheral neuropathy associated with dopaminergic damage.. Binienda ZK, Sarkar S, et al. 2013. Neurosci Lett. 541:233-7
- Environment-contact administration of rotenone: A new rodent model of Parkinson's disease.. Liu Y, Sun JD, Song LK, et al. 2015. Behav Brain Res.294:149-161
- Environmental Exposures and Parkinson's Disease.. Nandipati S, Litvan I. 2016. Int J Environ Res Public Health. 13(9).
- Environmental Neurotoxic Pesticide Exposure Induces Gut Inflammation and Enteric Neuronal Degeneration by Impairing Enteric Glial Mitochondrial Function in Pesticide Models of Parkinson’s Disease: Potential Relevance to Gut-Brain Axis Inflammation in Parki. Palanisamy, B.N., Sarkar, S., Malovic, E., Samidurai, M., Charli, A., Zenitsky, G., Jin, H., Anantharam, V., Kanthasamy, A. and Kanthasamy, A. The International Journal of Biochemistry & Cell Biology, p.106225.
- Paraquat Neurotoxicity is Distinct from that of MPTP and Rotenone. Richardson, J. et al. (2005) Paraquat Neurotoxicity is Distinct from that of MPTP and Rotenone, Toxicological Sciences. Available at: https://www.sciencedirect.com/science/article/pii/S0160412020322996?via%3Dihub.
- Risk of Parkinson disease associated with pesticide exposure and protection by probiotics. Rajawat, N. K., Bhardwaj, K., & Mathur, N. (2022). Risk of Parkinson disease associated with pesticide exposure and protection by probiotics. Materials Today: Proceedings, 69, A1-A11. https://www.sciencedirect.com/science/article/pii/S2214785322075253
- Pesticide-Induced Inflammation at a Glance. Lopes-Ferreira, M. et al. (2023) ‘Pesticide-induced inflammation at a glance’, Toxics, 11(11), p. 896. doi:10.3390/toxics11110896.
- Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons. Sharma, M., Kaur, J., Rakshe, S., Sharma, N., Khunt, D., & Khairnar, A. (2022). Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons. Neurotoxicity research, 40(1), 215–229. https://doi.org/10.1007/s12640-021-00436-9
Gateway Health and Environmental Effects Citations
1. Extension Toxicology Network (EXTOXNET) Pesticide Information Profiles. http://extoxnet.orst.edu/pips/ghindex.html
2. Yueh, MF et al. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. PNAS doi: 10.1073/pnas.141911911. Triclosan promotes liver cancer cell development and proliferation in mice through pathways common to humans.