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Pirimiphos-methyl

General Information

• Product Names:

  Dominator Insecticide Ear Tag (Intervet Inc D/B/A Merck Animal Health)
  Actellic® 5e Insecticide Low Odor Formulation (Winfield Solutions, LLC)
  Pirimiphos-Methyl Technical (Winfield Solutions, LLC)

• Chemical Class: Organophosphate
• Uses: As a broad-spectrum organophosphate insecticide and acaricide, pirimiphos-methyl is primarily used post-harvest on grains (corn, sorghum, wheat, barley, oats), seeds, and peanuts, as well as in domestic/industrial areas and in cattle ear tags. 
• Alternatives: Organic Agriculture, Organic Lawn Care
• Beyond Pesticides rating: Toxic

Health and Environmental Effects

• Cancer: Not documented
• Endocrine Disruption: Not documented
• Reproductive Effects: Yes (1)
• Neurotoxicity: Yes (2)
• Kidney/Liver Damage: Not documented
• Sensitizer/ Irritant: Yes (2)
• Birth/Developmental: Not documented
• Detected in Groundwater: Not documented
• Potential Leacher: Not documented
• Toxic to Birds: Not documented
• Toxic to Fish/Aquatic Organisms: Yes (1)
• Toxic to Bees: Yes (3)

Additional Information

• Regulatory Status:
  • EPA Tolerances for Residues
  • BP Comments February 2026
    
  • EPA Draft Human Health and Ecological Risk Assessments (2016)
• Supporting information:
  • World Health Organization Chemical Fact Sheets: Pirimiphos-methyl
  • PAN Pesticides Database: Pirimiphos-methyl (Pesticide Action Network)
  • NIH PubChem Database (National Library of Medicine)
• Studies [compiled from the Pesticide-Induced Diseases Database]
  • Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Anti-Androgens. Orton F, Rosivatz E, Scholze M, Kortenkamp A 2011. Environ Health Perspect. doi:10.1289/ehp.1002895
  • Residues of pesticides and metabolites in chicken kidney, liver and muscle samples from poultry farms in Dar es Salaam and Pwani, Tanzania. Mahugija, J. A. M., Chibura, P. E., & Lugwisha, E. H. J. (2018). Residues of pesticides and metabolites in chicken kidney, liver and muscle samples from poultry farms in Dar es Salaam and Pwani, Tanzania. Chemosphere, 193, 869–874. https://doi.org/10.1016/j.chemosphere.2017.11.094
  • Hepatotoxicity of Pirimiphos-Methyl on Wistar Rats. Nosiri, Chidi & Stanley C., Okereke & Uche Okuu, Arunsi & Chujor, O.O. & Nwaogwugwu, Caleb. (2017). Hepatotoxicity of Pirimiphos-Methyl on Wistar Rats. IOSR Journal of Environmental Science, Toxicology and Food Technology. 11. 88-93. 10.9790/2402-1104018893.
  • Effects of Pirimiphos-Methyl on Non-Target Invertebrates. Faly, L., & Brygadyrenko, V. (2024). Effects of Pirimiphos-Methyl on Non-Target Invertebrates. Biology, 13(10), 823. https://doi.org/10.3390/biology13100823
  • In Vitro Evaluation of the Combined Toxicity of Pirimiphos-methyl and Piperonyl Butoxide. Campos, F. et al. (2025). In Vitro Evaluation of the Combined Toxicity of Pirimiphos-methyl and Piperonyl Butoxide. Anais da Academia Brasileira de Ciencias, 97(4), e20241526. https://doi.org/10.1590/0001-3765202520241526