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Updates from the Daily News Blog

Pesticides Found in Marine Atmosphere Over Deep Atlantic Ocean, Documented for the First Time
April 16, 2025

Study Links Numerous Chemical Families of Pesticides to Endocrine Disrupting Effects, Including Obesity
December 17, 2024

EPA Registers Toxic Pesticide for Use on GE Soybeans without Required Opportunity for Public Comment
April 7, 2020

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Isoxaflutole

General Information

• Product Names:

  BALANCE PRO 
  EPIC DF 
  CORVUS 
  PREQUEL 
  

• Chemical Class: Isoxazole herbicide
• Uses: For use on field corn for the control of annual broadleaf weeds
• Alternatives: Organic Agriculture
• Beyond Pesticides rating: Toxic

Health and Environmental Effects

• Cancer: Likely (1)
• Endocrine Disruption: Yes (2)
• Reproductive Effects: Yes (1)
• Neurotoxicity: Not documented
• Kidney/Liver Damage: Yes (3, 1, 2)
• Sensitizer/ Irritant: Not documented
• Birth/Developmental: Yes (3, 1)
• Detected in Groundwater: Yes (4)
• Potential Leacher: Yes (5)
• Toxic to Birds: Not documented
• Toxic to Fish/Aquatic Organisms: Yes (3)
• Toxic to Bees: Not documented

Additional Information

• Regulatory Status:
  • EPA Factsheet
  • Petition for Determination of Nonregulated Status of Cotton Genetically Engineered for Resistance to Glyphosate and Isoxaflutole
• Supporting information:
  • Fluoride Action Network
    WHO Review
• Studies [compiled from the Pesticide-Induced Diseases Database]
  • Scribner, E.A.et al. 2006. Occurrence of isoxaflutole, acetamide, and triazine herbicides and their degradation products in 10 Iowa Rivers draining to the Mississippi and Missouri Rivers, 2004. USGS Report 2006-5169, 84 p.
  • Tomkiel, M., Baćmaga, M., Borowik, A., Kucharski, J. and Wyszkowska, J., 2019. Effect of a mixture of flufenacet and isoxaflutole on population numbers of soil-dwelling microorganisms, enzymatic activity of soil, and maize yield. Journal of Environmental Science and Health, Part B, 54(10), pp.832-842.
  • Impact of Endocrine Disrupting Pesticide Use on Obesity: A Systematic Review. Pérez-Bermejo, M. et al. (2024) Impact of Endocrine Disrupting Pesticide Use on Obesity: A Systematic Review, Biomedicines. Available at: https://www.mdpi.com/2227-9059/12/12/2677.
  • Currently used and legacy pesticides in the marine atmosphere from Patagonia to Europe. Debler, F., Gandrass, J., Paul Ramacher, M. O., Koenig, A. M., Zimmermann, S., & Joerss, H. (2025). Currently used and legacy pesticides in the marine atmosphere from Patagonia to Europe. Environmental pollution (Barking, Essex : 1987), 373, 126175. Advance online publication. https://doi.org/10.1016/j.envpol.2025.126175