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Vinclozolin

General Information

• Product Names:

  Ronilan (BASF)
  Curalan (BASF)

• Chemical Class: Morpholine fungicide
• Uses: Canola and imported grapes
• Alternatives: Organic agriculture
• Beyond Pesticides rating: Toxic

Health and Environmental Effects

• Cancer: Possible (1)
• Endocrine Disruption: Yes (2, 3)
• Reproductive Effects: Yes (1)
• Neurotoxicity: Not documented
• Kidney/Liver Damage: Not documented
• Sensitizer/ Irritant: Yes (1)
• Birth/Developmental: Not documented
• Detected in Groundwater: Not documented
• Potential Leacher: Not documented
• Toxic to Birds: Not documented
• Toxic to Fish/Aquatic Organisms: Yes (1)
• Toxic to Bees: Not documented

Residential Uses as Found in the ManageSafe™ Database

• Mold

Additional Information

• Regulatory Status:
  • RED signed 10/2000
• Supporting information:
  • PAN Pesticides Database: Vinclozolin (Pesticide Action Network)
• Studies [compiled from the Pesticide-Induced Diseases Database]
  • Effects of processing on pesticide residues in peaches intended for baby food.. Balinova AM, Mladenova RI, Shtereva DD. 2006. Food Addit Contam.23(9):895-901
  • Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat.. Gray LE, et al. 1999. Toxicol Ind Health;15(1-2):48-64
  • Effects of the endocrine disruptor vinclozolin in male reproduction: a systematic review and meta-analysis. Feijó, M., Martins, R.V., Socorro, S., Pereira, L. and Correia, S., 2021. Biology of Reproduction.
  • Environmentally induced epigenetic transgenerational inheritance of altered Sertoli cell transcriptome and epigenome: molecular etiology of male infertility.. Guerrero-Bosagna C, Savenkova M, Haque MM, et al. 2013. PLoS One. 8(3):e59922
  • Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility. Anway, M.D. et al. 2005. Science: 308(5727) pp. 1466 - 1469
  • Exploring associations between residential exposure to pesticides and birth outcomes using the Dutch birth registry. Simões, M., Vermeulen, R., Portengen, L., Janssen, N. and Huss, A., 2023. Environment International, p.108085.
  • Adverse Effects of Pesticides on the Ovary: Evidence from Epidemiological and Toxicological Studies. Wang, L., Ma, X. and Liu, J. (2025) Adverse Effects of Pesticides on the Ovary: Evidence from Epidemiological and Toxicological Studies, Environment & Health. Available at: https://pubs.acs.org/doi/full/10.1021/envhealth.4c00243.
  • The antiandrogenic vinclozolin induces differentiation delay of germ cells and changes in energy metabolism in 3D cultures of fetal ovaries. González-Sanz, S., Barreñada, O., Rial, E. et al. The antiandrogenic vinclozolin induces differentiation delay of germ cells and changes in energy metabolism in 3D cultures of fetal ovaries. Sci Rep 10, 18036 (2020). https://doi.org/10.1038/s41598-020-75116-3
  • Reduced birth weight in relation to pesticide mixtures detected in cord blood of full-term infants. Wickerham, Erin L et al. “Reduced birth weight in relation to pesticide mixtures detected in cord blood of full-term infants.” Environment international vol. 47 (2012): 80-5. doi:10.1016/j.envint.2012.06.007
  • Carcinogenicity of atrazine, alachlor, and vinclozolin. Cattley, R. C., De Roos, A. J., Mandrioli, D., Pearce, N., Pronk, A., Soshilov, A., Abarikwu, S. O., Baldi, I., Barr, D. B., Freeman, L. E. B., Bortoli, S., Connolly, A., Dalvie, M. A., Ferreira, M. J., Genter, M. B., Le Hégarat, L., Lorenzetti, S., McLaughlin, J. R., Møller, P., Montagner, C. C., … Schubauer-Berigan, M. K. (2025). Carcinogenicity of atrazine, alachlor, and vinclozolin. The Lancet. Oncology, S1470-2045(25)00702-8. Advance online publication. https://doi.org/10.1016/S1470-2045(25)00702-8