Gateway test
Tebufenozide
General Information
- Chemical Class: Diacylhydrazine insecticide
- Uses: Control of lepidopterans in forestry, ornamentals, grapes, blueberries, cranberries, nut trees, pome fruits, citrus, brassica, leafy vegetables, fruiting vegetables, canola, cotton, mint and turnip.
- Alternatives: Organic agriculture
- Beyond Pesticides rating: Toxic
Health and Environmental Effects
- Cancer: Possible (1)
- Endocrine Disruption: Possible (2)
- Reproductive Effects: Insufficiently Studied
- Neurotoxicity: Insufficiently Studied
- Kidney/Liver Damage: Yes (3); Blood Cell Damage (3)
- Sensitizer/ Irritant: Not Likely
- Birth/Developmental: Insufficiently Studied
- Detected in Groundwater: Possible (4)
- Potential Leacher: Possible (3, 4)
- Toxic to Birds: Insufficiently Studied
- Toxic to Fish/Aquatic Organisms: Yes (5)
- Toxic to Bees: Possible (3)
Residential Uses as Found in the ManageSafe™ Database
Additional Information
- Regulatory Status:
- Studies [compiled from the Pesticide-Induced Diseases Database]
- Current-use pesticides in vegetation, topsoil and water reveal contaminated landscapes of the Upper Rhine Valley, Germany. Mauser, K.M., Wolfram, J., Spaak, J.W. et al. Current-use pesticides in vegetation, topsoil and water reveal contaminated landscapes of the Upper Rhine Valley, Germany. Commun Earth Environ 6, 166 (2025). https://doi.org/10.1038/s43247-025-02118-2
Gateway Health and Environmental Effects Citations
1. Xu, W., Wang, B., Yang, M., Zhang, Y., Xu, Z., Yang, Y., Cao, H. and Tao, L., 2017. Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells. Environmental toxicology and pharmacology, 49, pp.89-96. https://doi.org/10.1016/j.etap.2016.12.002
2. Lee, W.C. and Kwak, I.S., 2005. The Mentum deformity of C. plumosus following exposure to endocrine disruption chemicals. Korean Journal of Ecology and Environment, 38(1), pp.11-17. https://www.koreascience.or.kr/article/JAKO200518317183916.page
3. The University of Hertfordshire. 2021. PPDB: Pesticide Properties DataBase - Tebufenozide https://sitem.herts.ac.uk/aeru/ppdb/en/Reports/611.htm
4. European Food Safety Authority, 2010. Conclusion on the peer review of the pesticide risk assessment of the active substance tebufenozide. EFSA Journal, 8(12), p.1871. https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/j.efsa.2010.1871
5. Pesticide Action Network Pesticide Database. http://www.pesticideinfo.org/Search_Chemicals.jsp.








.png)