Gateway test

Chlorpropham (CIPC)

General Information

• Product Names:

  Biox (Pace)
  Aceto Spud Nic-3 EC (Aceto)
  Spud Guard (Dataplex)
  Sprout Nip (Loveland)

  Decco (Decco Us Post-Harvest, Inc.)

• Chemical Class: Carbamate Herbicide
• Uses: Control of mouseear chickweed in spinach, also used as part of an IPM method to decrease incidence of Botrytis infection (a fungal disease) in Easter lilies. As a plant growth regulator inhibits sprouting in stored potatoes and controls fruiting in ginkgo trees.
• Alternatives: Organic Agriculture, Non-Toxic Lawns and Landscapes
• Beyond Pesticides rating: Toxic

Health and Environmental Effects

• Cancer: Suspected (1)
• Endocrine Disruption: Suspected (1)
• Reproductive Effects: Yes (2)
• Neurotoxicity: Not documented
• Kidney/Liver Damage: Yes (2, 1)
• Sensitizer/ Irritant: Not documented
• Birth/Developmental: Yes (2)
• Detected in Groundwater: Not documented
• Potential Leacher: Yes (3)
• Toxic to Birds: Not documented
• Toxic to Fish/Aquatic Organisms: Yes (2, 1)
• Toxic to Bees: Not documented

Additional Information

• Regulatory Status:
  • EPA Reregistration Eligibility Decision (RED) Signed 10/1996
• Supporting information:
  • PAN Pesticides Database: Chlorpropham (Pesticide Action Network)
  • Chlorpropham Factsheet (EXTOXNET)
  • PubChem Hazardous Substances Database (National Library of Medicine)
• Studies [compiled from the Pesticide-Induced Diseases Database]
  • Chlorpropham, a carbamate ester herbicide, has an endocrine-disrupting potential by inhibiting the homodimerization of human androgen receptor. Jeong, Da-Hyun & Jung, Da-Woon & Jang, Cheol-Ho & Kim, Uk-Jin & Park, Yooheon & Park, Yeonhwa & Lee, Hee-Seok. (2023). Chlorpropham, a carbamate ester herbicide, has an endocrine-disrupting potential by inhibiting the homodimerization of human androgen receptor. Environmental Pollution. 325. 121437. 10.1016/j.envpol.2023.121437.
  • Developmental toxicity of chlorpropham induces pathological changes and vascular irregularities in zebrafish embryos. Lee, J. Y., Park, H., Lim, W., & Song, G. (2020). Developmental toxicity of chlorpropham induces pathological changes and vascular irregularities in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 236, 108802. https://doi.org/10.1016/j.cbpc.2020.108802
  • Wastewater surveillance for assessing human exposure to pesticides: Investigating populations living near flower bulb fields. Bijlsma, L. et al. (2025) Wastewater surveillance for assessing human exposure to pesticides: Investigating populations living near flower bulb fields, Journal of Environmental Chemical Engineering. Available at: https://www.sciencedirect.com/science/article/pii/S2213343725017865.
  • Trends in airborne pesticides: A retrospective analysis of the last two decades (2007–2024) in a Mediterranean Region. López, A., Fuentes-Ferragud, E., Muñoz, A., Borràs, E., Vera, T., & Coscollà, C. (2025). Trends in airborne pesticides: A retrospective analysis of the last two decades (2007-2024) in a Mediterranean Region. Environmental pollution (Barking, Essex : 1987), 383, 126770. Advance online publication. https://doi.org/10.1016/j.envpol.2025.126770
  • Chlorpropham induces mitochondrial dysfunction in rat hepatocytes. Nakagawa, Y., Nakajima, K., & Suzuki, T. (2004). Chlorpropham induces mitochondrial dysfunction in rat hepatocytes. Toxicology, 200(2-3), 123–133. https://doi.org/10.1016/j.tox.2004.03.012
  • Subchronic toxicity of chlorpropham (CIPC) in ICR mice. Fujitani, T., Tada, Y., Fujii, A., Kimura, M., & Yoneyama, M. (2000). Subchronic toxicity of chlorpropham (CIPC) in ICR mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 38(7), 617–625. https://doi.org/10.1016/s0278-6915(00)00043-0
  • Developmental toxicity of chlorpropham in mice. Tanaka, T., Fujitani, T., Takahashi, O., Oishi, S., & Yoneyama, M. (1997). Developmental toxicity of chlorpropham in mice. Reproductive toxicology (Elmsford, N.Y.), 11(5), 697–701. https://doi.org/10.1016/s0890-6238(97)00030-0