Gateway test

Methoxychlor

General Information

• Fact Sheet: Methoxychlor.pdf
• Product Names:

  Bonide Rose and Flower (Bonide Products), formulated with Carbaryl, Malathion, Captan
  Ortho Home Orchard Spray (Monsanto), forumlated with Malathion, Captan
  E-Z-FLO Crop Guard (Bayer Cropscience), formulated with Diazinon, Xylene
  Rockland General Purpose Dust (Value Garden Supply), formulated with Malathion, Captan
  Purina Horse Spray (Purina Mills), formulated with Butoxypolypropylene glycol
  Prentox Mosquito Yard Spray (Prentiss), formulated with Malathion

• Chemical Class: Organochlorine insecticide
• Uses: No registered uses. Historically used on cockroaches, mosquitoes, flies and chiggers, as well as various arthropods that attack field crops, vegetables, fruits, ornamentals, stored grain, livestock, and domestic pets.
• Alternatives: Organic Agriculture, Least-toxic insect control
• Beyond Pesticides rating: Toxic

Health and Environmental Effects

• Cancer: Not documented
• Endocrine Disruption: Known (1)
• Reproductive Effects: Yes (2)
• Neurotoxicity: Yes (2)
• Kidney/Liver Damage: Yes (2)
• Sensitizer/ Irritant: Not documented
• Birth/Developmental: Not documented
• Detected in Groundwater: Yes (2)
• Potential Leacher: Not documented
• Toxic to Birds: Not documented
• Toxic to Fish/Aquatic Organisms: Yes (2)
• Toxic to Bees: Not documented

Additional Information

• Regulatory Status:
  • EPA Reregistration Eligibility Decision (RED) signed (6/2004)
• Supporting information:
  • Extoxnet Methoxychlor Factsheet (Extension Toxicology Network)
  • PAN Pesticides Database:Methoxychlor (Pesticide Action Network)
  • Scorecard Methoxychlor Factsheet (Environmental Defense Fund)
• Studies [compiled from the Pesticide-Induced Diseases Database]
  • The Effects of Perinatal/Juvenile Methoxychlor Exposure on Adult Rat Nervous, Immune, and Reproductive System Function. Chapin, R. E., Harris, M. W., Davis, B. J., Ward, S. M., Wilson, R. E., Mauney, M. A., Lockhart, A. C., Smialowicz, R. J., Moser, V. C., Burka, L. T., & Collins, B. J. (1997). The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundamental and applied toxicology : official journal of the Society of Toxicology, 40(1), 138–157. https://doi.org/10.1006/faat.1997.2381
  • Pesticide residue in cucumber-exposed plants, and its associated effects on soil nematode population. Imonikebe, P. et al. (2025) Pesticide residue in cucumber-exposed plants, and its associated effects on soil nematode population, Advances in Modern Agriculture. Available at: https://www.researchgate.net/publication/390847748_Pesticide_residue_in_cucumber-exposed_plants_and_its_associated_effects_on_soil_nematode_population.
  • Mapping pesticide-induced metabolic alterations in human gut bacteria. Chen, L. et al. (2025) Mapping pesticide-induced metabolic alterations in human gut bacteria, Nature Communications. Available at: https://www.nature.com/articles/s41467-025-59747-6.
  • Pesticides in surface water of the Ondas river watershed, western Bahia, Brazil: Spatial-seasonal distribution and risk assessment. do Rego EL, de Souza JR, Nakamura TC, Portela JF, Diniz PHGD, da Silva JDS. Pesticides in surface water of the Ondas river watershed, western Bahia, Brazil: Spatial-seasonal distribution and risk assessment. Chemosphere. 2024 Apr;354:141659. doi: 10.1016/j.chemosphere.2024.141659. Epub 2024 Mar 13. PMID: 38490616.