(Beyond Pesticides, March 13, 2025) Study results published in Pesticide Biochemistry and Physiology “suggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal barrier.” The researchers studied the toxic effects of the insecticides abamectin and spirodiclofen, as well as the fungicide fluazinam, individually and in combination. In exposing mice and Caco-2 cells to these pesticides, the results show the disruption of intestinal functions and highlight the need to assess potential synergistic effects of pesticide mixtures as a part of the regulatory review process.  Effects on the intestinal barriers of mice represent a threat to “the first line of defense against the external environment,” the researchers say. The intestinal mucosal epithelial structure plays an important role in preventing harmful substances from entering the intestines and causing damage to cells.  [Caco-2 cells represent a human cell line, derived from a colon cancer patient’s tissue, and mimic the small intestine. These cells are vital in research as a model of the intestinal epithelial barrier.]  “Currently, most studies investigating the effects of pesticide residues on the barrier function of Caco-2 cells concentrate on the exposure to a single residue, while the potential toxic effects arising from the concurrent presence of multiple pesticide […]

(Beyond Pesticides, March 11, 2025) A study in Toxics analyzes ipconazole, a triazole fungicide often used as a coating on treated seeds and as a foliar treatment on the leaves of plants. “Triazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms,” the researchers state. In the current study, unintended reproductive effects are noted in male sheep (ram) and pigs (also known as porcine or swine). This research focuses on the impact of ipconazole exposure on spermatozoa (sperm) in two mammal species and finds spermiotoxicity through significantly reduced sperm viability, as well as alterations in enzyme and gene expression related to fertility.  “To our knowledge, this is the first study to evaluate the cytotoxic effect of the triazole ipconazole on mammalian spermatozoa,” the authors share. This analysis utilizes semen samples from the Reproductive Biotechnology Laboratory of the Major National University of San Marcos in Lima, Peru, the university where six of the nine researchers are Faculty of Veterinary Medicine.   “The sperm were exposed to ipconazole concentrations of 1, 5, 10, 50 and 100 µM, and to a control without ipconazole,” they say. Similar concentrations have been used in previous cytotoxicity studies with ipconazole. […]

(Beyond Pesticides, March 10, 2025) Following International Women’s Day, celebrated on March 8, 2025, the poignant findings on women, gender, and hazardous substances in a United Nations report raise critical issues of concern and cause for urgent action to phase out petrochemicals. The Report of the Special Rapporteur on the implications for human rights of the environmentally sound management and disposal of hazardous substances and wastes, by Marcos Orellana, was delivered to the 79th Session of the United Nations General Assembly in July 2024. Excerpts from the report follow: “Women make up roughly 60 to 70 per cent of the agricultural labour force in developing countries where pesticides and pesticide handling are especially poorly regulated. In Zambia, for example, two thirds of the labour force is engaged in agriculture, and 78 per cent are women farmers and peasants. Women there play a significant role in pesticide application, often without any or adequate personal protective equipment, especially during activities such as weeding, harvesting, and washing pesticide-laden clothes.” “In higher-income countries, women who do agricultural work are often poor and/or migrants; pesticides are one of many dimensions of marginalization and damage to their well-being. The European agriculture sector uses many seasonal and […]

(Beyond Pesticides, March 7, 2025) In honor of International Women’s Day on Saturday, March 8, 2025, Beyond Pesticides sheds light on the disproportionate risks to women from toxic chemicals that are often unaccounted for and even dismissed throughout pesticide regulatory review and the underlying statutes. In a roundup of Daily News coverage in 2024, as well as the most recent scientific studies in 2025, on the scientific links between pesticide exposure and adverse effects in women, this article highlights the growing inequities in pesticide threats to women’s health.  Women farmers and farmworkers are particularly excluded when assessing pesticide risks. As previously reported by Beyond Pesticides, a study published in Occupational and Environmental Medicine finds that pesticide exposure, especially during puberty, can play a role in ovarian cancer development among female farmers. Although there are many studies that evaluate the risk for cancers among farmers, very few scientific articles cover the risk of ovarian cancer from pesticide exposure.  Additionally, this study suggests the role of hormones in ovarian cancer prognosis and development, highlighting an association with endocrine disruption. Endocrine disruption can lead to numerous health problems in multiple organ systems, including hormone-related cancer development (e.g., thyroid, breast, ovarian, prostate, testicular), reproductive […]

(Beyond Pesticides, March 4, 2025) A study in GeoHealth of pediatric cancers in Nebraska links exposure to agricultural mixtures with the occurrence of these diseases. The authors find statistically significant positive associations between pesticide usage rates and children with cancer, specifically brain and central nervous system (CNS) cancers and leukemia. “Our study is the first to estimate the effect of an agrichemical mixture on the pediatric cancer rate in Nebraska,” the study authors share. “One significant advantage of our study is that we identified the pesticide consistently applied over 22 years in Nebraska counties and then estimated the overall mixture effect of these pesticides on pediatric cancer.” The elevated effect of pesticide mixtures, a reality that is not evaluated in the U.S. Environmental Protection Agency’s (EPA) pesticide registration program, was reported in Oecologia (2008), documenting harm to amphibian populations even if the concentration of the individual chemicals is within limits considered acceptable. (See additional coverage here.) There is a wide body of science highlighting the disproportionate risk of adverse health effects in children with pesticide exposure. Their small size and developing organ systems, propensity to crawl and play near the ground, tendency for frequent hand-to-mouth motion, and greater intake of […]

(Beyond Pesticides, February 28, 2025) It is well established that children are more vulnerable than adults to environmental insults such as pesticides, from conception onward. Children living in agricultural areas are exposed differently from those in urban areas. A study of rural children by researchers at Mexico’s Universidad Atónoma de Nayarit compared two communities located less than a quarter of a mile from agricultural fields with one control community located more than a mile away. The study shows that children in the field-adjacent towns are clearly exposed to pesticides and are experiencing cellular distress as a result. The state of Nayarit is on the west coast of Mexico near Mazatlan. Rural children encounter aerial application, spray drift, and erosion. If their parents are agricultural workers and especially if they apply pesticides, they bring home residues on their clothes. Residential storage of pesticides and small children’s propensity to play in the dirt and put things in their mouths exacerbate their exposure. Urban children get hit by pesticides in their homes, schools, and parks. The researchers took blood and urine samples from 431 children aged six to 12 and collected questionnaires as to pesticide exposures from the parents or guardians. They assayed the […]

(Beyond Pesticides, February 27, 2025) In analyzing current scientific literature and data on glyphosate-based herbicides (GBHs), a research article in Environmental Sciences Europe finds that glyphosate (GLY) persists in bones before reentering the bloodstream. The mechanisms in which GLY interacts with important cells for development, called hematopoietic stem cells (HSCs), and breaks and rearranges DNA offer a possible explanation for the heightened risk of cancer, specifically blood cancers like non-Hodgkin lymphoma (NHL), myeloma, and leukemia. “Existing data on GLY/GBH metabolism and genotoxicity provide critical insights into how exposures may be contributing to blood cancers,” according to the study’s author, Charles Benbrook, PhD. Dr. Benbrook continues: “A significant portion of GLY reaching blood moves quickly into bone marrow and then bone, where it can bioaccumulate and persist… Data reviewed herein suggest that a portion of the GLY excreted by most people on a daily basis can be traced to the shedding of calcium-GLY complexes in bone back into the blood supply.” This allows for near-constant contact between glyphosate molecules and hematopoietic stem cells, which are immature cells that can develop into any type of blood cell. Mutations in hematopoietic stem cells can cause blood cancers to emerge. Those at disproportionate risk […]

(Beyond Pesticides, February 21, 2025) The prospects for rational environmental policies in the U.S., including commitments to biodiversity and public health protections, are in disarray as the Trump administration sweeps through the federal government without any evaluation of program importance or effectiveness. At the U.S. Environmental Protection Agency (EPA), the destruction is likely to derail or reverse reasonable decisions to ban or restrict numerous toxic chemicals and to bury concern for ecosystem-wide harms. On biodiversity, President Trump has killed a major report, the National Nature Assessment, that had been due for completion on February 11. The assessment is part of the U.S. Global Change Research Program, which produces the national climate assessment, but it was created by an executive order issued under President Biden rather than by Congress. More than 150 experts, including federal employees and volunteers from academia, nonprofits, and businesses, reviewed the state of the nation’s lands, water, and wildlife. The assessment is a U.S.-specific version of a recent global report from the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES), covered here by Beyond Pesticides. The IPBES details the many steps that can be taken at every level of the problem to preserve the ecosystem services […]

(Beyond Pesticides, February 11, 2025) In a Science of The Total Environment study, scientists test over 100 blue tit (Cyanistes caeruleus) and great tit (Parus major) birds’ nests for pesticide residues in comparison with the number of dead offspring and unhatched eggs within the nest. Fur-lined nests, from animals treated with ectoparasitic chemicals, expose birds to compounds that can impact reproductive success. The authors found fipronil, a phenyl pyrazole insecticide, in all nests, with the majority also containing the neonicotinoid insecticide imidacloprid and synthetic pyrethroid insecticide permethrin. The data shows higher insecticide levels are linked to increased offspring mortality and threaten biodiversity. This study highlights an important exposure route that is overlooked. “Although not all bird species use fur for nest building, a substantial number do, especially cavity-nesting species,” the researchers share. “Previous research found that 74% of studied woodland bird species in central Europe incorporated fur into their nests.” Many bird species in the U.S. also line their nests with fur, such as black-capped chickadees, tufted titmice, and chipping sparrows. While there is a wide body of science showing reproductive effects from pesticides, the researchers highlight the study’s novel design, saying, “To the best of our knowledge, no previous […]

(Beyond Pesticides, February 10, 2025) With the shutting down of key federal government programs, Beyond Pesticides is urging the public to speak out, especially on issues that preserve state and local authority to protect public health and safety in the absence of adequate federal standards. In this context, the U.S. Environmental Protection Agency (EPA) is considering a petition with a proposed policy that would, if adopted, prohibit states from issuing warnings of pesticide hazards, like cancer, on product labels. EPA is taking public comment through February 20, 2025, on the petition, filed by the Republican attorneys general (AGs) of 11* states.  The petition asks EPA to prohibit “any state labeling requirements inconsistent with EPA findings and conclusions from its human health risk assessment on human health effects, such as a pesticide’s likelihood to cause cancer, birth defects, or reproductive harm.” [*The 11 states filing the petition include: Alabama, Arkansas, Georgia, Indiana, Iowa, Louisiana, Montana, Nebraska, North Dakota, South Carolina, and South Dakota.] According to Beyond Pesticides: “The only conclusion that can be derived from this petition is that the AGs do not care if the people, including farmers, of their states are harmed by pesticides, and they should not be able […]

(Beyond Pesticides, February 6, 2025) Months after publishing a June 2024 study regarding concentrations of pesticides discovered in legal (and illegal) cannabis products in California, the Los Angeles Times has released a follow-up exposé highlighting extensive pesticide contamination, including from “hidden” pesticides that regulators have not monitored. The authors conclude that in California’s legal weed market, over half of available smoking products are found to contain hidden chemicals—toxic pesticides present in products but not regulated or monitored by state authorities. Since 2015, Beyond Pesticides has laid out health, safety, and environmental concerns related to the contamination of cannabis by pesticides (and fertilizers) alongside an imperative need to mandate an organic systems approach to cannabis production. Yet ten years later, it appears nationally that California state regulators are alone in moving forward in 2021 with state organic cannabis certification. There are other marketplace-based cannabis certification labels that require comparable organic certification practices (see Beyond Pesticides reporting here and here). For more information, please see past Pesticides and You reporting here and here. The Los Angeles Times analyzed the results from state licensed laboratory testing of more than 370 legal cannabis products, representing 86 brands. In addition to the 66 chemicals required […]

(Beyond Pesticides, February 5, 2025) A study in PLOS One finds acute and chronic impacts of nontarget toxicity on the American burying beetle, Nicrophorus americanus, with neonicotinoid insecticide exposure. In assessing environmentally relevant concentrations of the neonicotinoid insecticide imidacloprid with N. americanus, the researchers note both mortality and behavioral effects that leave the species at high risk of predation. These effects mean the American burying beetle “may be at greater risk to insecticide exposure than previously thought and vulnerable to episodic, low-dose neonicotinoid exposure,” the authors say. This data sheds important light on a species that has been listed by the U.S. Fish and Wildlife Service (USFWS) as threatened. Burying beetles provide important ecosystem services within the environment such as “burying carrion, increasing available nutrients in soil, and expediting carrion decomposition, while acting as a food source for secondary consumers,” the researchers state. (See more on ecosystem services and beneficial insects here, here, and here.) The N. americanus species are habitat generalists and can be found in grasslands, wet meadows, and forested areas that neighbor agricultural lands and introduce the beetles to pesticide drift and soil residues. While acute and chronic effects vary in duration and severity, pesticide exposure resulting […]

(Beyond Pesticides, February 3, 2025) As a result of executive orders on January 20, 2025 and subsequent actions by the Trump administration, the public airwaves have been flooded with presidential proclamations, some of which have been subject to legal action and outrage. While the president has issued dozens of executive orders dismantling programs—from the environment to foreign aid, the impact of the orders on the functioning of an independent government workforce has been raised by those targeted. On January 29, the American Federation of Government Employees (AFGE) and the American Federation of State, County and Municipal Employees (AFSCME) filed a lawsuit that “asserts that President Trump illegally exceeded his authority in attempting to unilaterally roll back a regulation that protects the rights of civil servants,” according to an AFGE press release. The release continues, “The suit also names the Office of Personnel Management for its role in failing to adhere to the Administrative Procedure Act in its attempts to roll back this same regulation.” According to AFGE National President Everett Kelley, “AFGE is filing suit with our partner union today to protect the integrity of the American people’s government,” On January 27, U.S. Equal Employment Opportunity Commission Chair and Commissioner Charlotte Burrows, having […]

(Beyond Pesticides, January 30, 2025) A research article in Biology Letters, published by The Royal Society, finds that the neonicotinoid insecticide imidacloprid disrupts survival and reproductive patterns in Bombus impatiens bumblebees. The study adds to the wide body of science highlighting how exposure to pesticides “can result in immediate mortality or cause long-term detrimental effects on pollinators‘ health, lifespan and reproductive success,” the authors state. The researchers performed two experiments to assess the effects of various concentrations of imidacloprid, one of which focuses on bees during diapause, a period of dormancy. “Wild bees, which provide the majority of pollination services worldwide, undergo an annual life cycle that includes a winter diapause, that can span over 75% of their life cycle and during which their metabolism, growth and development are halted,” the authors note. They continue: “The time spent in diapause can have lasting effects on pollinator fitness and their ability to establish nests or colonies in the following spring. This period is especially critical for social bee colonies, which are founded by a single queen after diapause and play a vital role in large-scale pollination.” Exposure to pesticides during diapause can occur while bee species overwinter in contaminated soils. In […]

(Beyond Pesticides, January 28, 2025) Beyond Pesticides is urging the U.S. Environmental Protection Agency (EPA) to move more cautiously in  its proposal for “streamlined . . . registration review decisions for several biopesticides,” subject to a public comment period through February 10, 2025. The organization is raising EPA review process concerns. The organization states: “Although the biopesticides listed in EPA’s proposal for streamlining the registration review process for ‘low risk biopesticides’ can be considered relatively low risk compared to conventional pesticides, the precedent for relying on the original or previous registration data and review is troublesome. EPA’s rationale for registration review—that ‘science is constantly evolving, and new scientific information can come to light at any time and change our understanding of potential effects from pesticides,’ should guide the agency in its decisions—especially when previous decisions have depended on limited actual data, data waiver request rationales, and purported absence of new data or adverse incidents reported.”  While Beyond Pesticides advocates for allowance of pesticides compatible with organic standards that are protective of human health, biodiversity, and healthy ecosystems, it urges EPA to establish rigorous standards in its registration review of these materials. The issue of biopesticide review is made complicated by the […]

(Beyond Pesticides, January 24, 2025) Based on data collected from government sources and independent monitoring, a multidisciplinary team of researchers at the University of Connecticut finds that 46% of Connecticut waterway samples are contaminated with levels of the neonicotinoid insecticide, imidacloprid—one of the most widely used insecticides in the United States on lawn and golf courses. The authors relied on federal data from U.S. Environmental Protection Agency (EPA) and U.S. Geological Survey (USGS), state-level data from Connecticut Department of Energy and Environmental Protection (CT-DEEP), and a small-scale data collection study by the Clean Rivers Project funded by the nonprofit Pollinator Pathway, Inc. In their report, Neonicotinoids in Connecticut Waters: Surface Water, Groundwater, and Threats to Aquatic Ecosystems, the researchers provide the most comprehensive view to date of neonicotinoid levels in Connecticut and offer critical recommendations for future testing within the state and nationally, given glaring data gaps. It is important to note that the authors acknowledged early in the report the “abandonment” of Integrated Pest Management in “the use of neonicotinoids has coincided with and been implicated in the decline of many non-target species of insects, in particular pollinators such as bees () and monarch butterflies.” They point out that […]

(Beyond Pesticides, January 22, 2025) A study published in Nature Scientific Reports in December 2024 sheds light on how people value the benefits of reducing or eliminating pesticide exposures. The study, based on economic concepts, is a meta-analysis of studies that have attempted to discern what that value is in monetary terms. This study shows the difficulty in gleaning from the existing literature an assignment of true value of social costs associated with pesticide contamination and poisoning, however, was able to glean several points of interest: People’s “willingness to pay” (WTP) is higher for health benefits than ecological ones. In studies that included pesticide risks associated with cancer, the social cost (WTP) tripled. People’s WTP is higher to prevent or ameliorate chronic diseases than to treat or avoid acute exposures. If the study did not specify a pesticide type—even general categories such as herbicide, insecticide and fungicide, and most studies fell into this category—the WTP is significantly higher. In ecosystem terms, use of the term “biodiversity” results in higher WTPs compared to other aspects such as groundwater or aquatic organism health. Consumers are more risk-averse than farmers. The higher the income, the higher the WTP. Social cost is distinguished from the […]

(Beyond Pesticides, January 13, 2025) The U.S. Environmental Protection Agency (EPA) is officially taking comments on whether to issue new restrictions on the herbicide atrazine’s use. Beyond Pesticides is telling the agency that it is time to recognize the biodiversity destruction that atrazine is causing and the viability of alternative organic management practices. The group has released an action and is asking the public to join this campaign to ban atrazine. As a yardstick for what is possible under existing federal pesticide law (the Federal Insecticide, Fungicide, and Rodenticide Act), EPA on August 7, 2024 announced that it was taking emergency action to ban the weed killer Dacthal (or DCPA–dimethyl tetrachloroterephthalate), leaving many people asking, “Why Dacthal and not other very hazardous pesticides?” The weed killer atrazine (in the triazine chemical family) poses similar elevated hazards to people and the environment, has proven to be impossible to contain, and has viable alternatives. Therefore, we need to challenge EPA to apply the same standard that removed Dacthal from the market to the long list of pesticides that are contributing to a health crisis, biodiversity collapse, and the climate emergency.  In its current proposal, EPA is choosing to downplay atrazine’s risk to ecosystems, allow more contamination with […]

(Beyond Pesticides, January 8, 2025) On the brink of the second Trump administration, a legal victory just last month overturned a rule issued under the first Trump administration to “practically eliminate oversight of novel GE technology and instead let industry self-regulate,” as characterized by the Center for Food Safety (CFS). CFS served as counsel in the case for the plaintiffs, led by the National Family Farm Coalition. The U.S. District Court for the Northern District of California decision, responding to the lawsuit filed in 2021 on behalf of farm and environmental groups, remanded the case back to the U.S. Department of Agriculture (USDA) with instructions to follow. “This is a critical victory on behalf of farmers, the planet, and scientific integrity,” says George Kimbrell, legal director at the Center for Food Safety, also a plaintiff in the case. Mr. Kimbrell continued, “USDA tried to hand over its job to Monsanto and the pesticide industry and the Court held that capitulation contrary to both law and science.” It remains to be seen whether the incoming Trump administration will appeal this court decision. Unpacking The Center for Food Safety Litigation This legal battle began in 2004 with the Animal and Plant Health […]

(Beyond Pesticides, January 7, 2025) A report, released in December 2024 from the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES), confronts the problem of “siloing” environmental elements—food, health, water, biodiversity and climate change—when they instead intersect at a nexus from which each element affects all the others. The problem is essentially that all the elements are part of the same crisis, yet actions to address issues within each—and, importantly, to resist addressing them—are dealt with in isolation. A proper perspective, gleaned from the report, is to view each element from the center where all parts meet, thus addressing the issues in coordination. According to the IPBES report, “[F]ragmented governance of biodiversity, water, food, health and climate change with different institutions and actors often working on disconnected and siloed policy agendas, resulting in conflicting objectives and duplication of efforts.” The IPBES is an independent body analogous to the Intergovernmental Panel on Climate Change (IPCC) but structured similarly and in close contact with the United Nations (UN). The new report comes at the behest of IPBES’s 147 member countries—75 percent of the UN’s membership—to address the interconnections among the five global crises. The report strongly demonstrates that a holistic, globe-spanning frame […]

(Beyond Pesticides, January 3, 2025) Pesticides that are sprayed and become airborne significantly disrupt ecological balances and affect nontarget species that are crucial for maintaining biodiversity, according to an article in Environmental Pollution. In this review of studies throughout countries in North and South America, Europe, and Asia, among others, researchers from Germany, Norway, the United Kingdom, and Poland reinforce the science about pesticides’ direct effect on species and the cascading effects of pesticide drift through various trophic levels within food webs that lead to overall devasting population effects. This study “addresses the interconnectedness of these impacts and illustrates the complex threats that pesticide drift poses to biodiversity across multiple ecosystems,” the researchers state. They continue: “Impacts include reduced reproductive rates, changes in growth, development, and/or behavior, modification of diversity or community organization, disruption of food webs, and declines of important species. Pesticides disrupt the delicate balance between species that define a functioning ecosystem. Impacts can be local, transnational, or even continental.” Pesticide drift threatens beneficial species and subsequently the entire agricultural system. The process of pesticide drift, “in which up to 25% of applied pesticides are carried by air currents, can transport chemicals over hundreds or even thousands of […]

Image: Art Page submission from Carol Moyer, “Monarch Butterfly Sideways with Closed Wings.“ (Beyond Pesticides, December 20, 2024) On December 12, the U.S. Fish and Wildlife Service (FWS) opened a public comment period on its proposal to list the monarch butterfly (Danaus plexippus) as a threatened species and to designate critical habitats for the species under the Endangered Species Act of 1973. Under the proposal, the designated habitats would span approximately 4,395 acres throughout overwintering sites in coastal California. The public comment period will be open until March 12, 2025. These suggested protections call attention to the role of chemical-intensive agriculture in affecting populations of pollinators and other beneficial organisms. George Kimbrell, legal director at the Center for Food Safety, shares in a press release that the “monarch listing decision is a landmark victory 10 years in the making. It is also a damning precedent, revealing the driving role of pesticides and industrial agriculture in the ongoing extinction crisis… But the job isn’t done: Monarchs still face an onslaught of pesticides. The Service must do what science and the law require and promptly finalize protection for monarchs.” In the docket, FWS states, “Under the Act, a species warrants listing if […]

(Beyond Pesticides, December 18, 2024) A bombshell investigation conducted by Canada’s National Observer finds that Bayer, which acquired the Monsanto chemical company in 2018, colluded with environmental and public health regulators in Canada to obstruct a proposed neonicotinoid insecticide ban originally introduced in 2018. Advocates were stunned back in 2021 when Canada’s Pest Management Regulatory Agency (PMRA)—the Canadian counterpart to the U.S. Environmental Protection Agency (EPA)—reversed its decision to phase out imidacloprid, clothianidin, and thiamethoxam by 2023. The weaponization of scientific institutions and regulatory processes is commonplace in the U.S. context, with U.S. Right to Know publishing a report earlier this year on the corrupting impact of pesticide manufacturers at the Entomological Society of America 2023 annual meeting. (See Daily News here.) There are numerous Office of Inspector General (OIG) reports signaling EPA corruption and failures, including persisting industry influence in the cancer risk assessment process, inadequate leadership in addressing community harms of a former creosote-treated wood preservative plant turned Superfund site in Pensacola, Florida, and failure to protect the public from endocrine-disrupting chemicals, to name several examples. In a recent press release, the David Suzuki Foundation, alongside numerous medical, legal, and civil society organizations, is calling on Health Canada […]