(Beyond Pesticides, April 14, 2026) A novel study mapping pesticide mixtures and cancer risk, published in Nature Health, “reveals a robust spatial association between environmental pesticide exposure risk and cancer incidence.” The team of international researchers incorporates pesticide risk modeling with Peruvian National Cancer Institute (INEN) registry data to map pesticide-induced cancer clusters in Peru, finding significant associations between pesticide mixtures and cases of carcinogenicity. The study analyzes 31 active ingredients to identify pesticide-associated cancer hotspots, none of which are classified as carcinogenic on their own by international standards. When combined as pesticide mixtures, as experienced in real-world environments, heightened risks and synergistic effects are noted. “Collectively, these findings strongly support a mechanistic [causal] link between pesticide exposure and cancer, challenging assumptions of human non-carcinogenicity derived from reductionist experimental models,” the authors state. “This study redefines the exposome [measure of all environmental, dietary, lifestyle, and social exposures of an individual] as a lineage-conditioned, mechanistically tractable framework and shows how complex pesticide mixtures can contribute to carcinogenic trajectories, with profound and far-reaching implications for global health policy and socio-ecological equity.” Background An extensive body of scientific literature connects individual pesticide active ingredients to a wide array of health and environmental effects […]

(Beyond Pesticides, April 10, 2026) An important study not previously covered in Daily News, “Use of Genetically Modified Organism (GMO)-Containing Food Products in Children,” raises serious concerns about children’s dietary exposure to pesticides, particularly the weed killer glyphosate, that are heavily used in the production of genetically engineered crops. Published in Pediatrics by the American Academy of Pediatrics, the lead authors Steven A. Abrams, MD, FAAP, Jaclyn Lewis Albin, MD, FAAP, and Philip J. Landrigan, MD, FAAP call attention to the widespread use of genetic engineering (GE) and GMOs in the U.S. food supply and the subsequent health risks for children and consumers. The authors, in collaboration with the Committee on Nutrition, Council on Environmental Health and Climate Change Executive Committee, and additional medical professionals and researchers, also maintain that pediatricians have the opportunity to provide education and “lead conversations with families about the health impact of certain foods, provide nutritional guidance, and help filter the overwhelming volume of information.” By supporting parents in making informed nutrition choices, pediatricians can help shape decisions that impact the long-term health of children and advocate for choosing organic certified products. As the authors state: “Although GMO technology could be used to increase the micronutrient […]

(Beyond Pesticides, April 7, 2026) In the International Journal of Molecular Sciences, a study of gestational (during pregnancy) exposure to the neonicotinoid insecticide thiacloprid shows epigenetic effects (alterations in genes without altering underlying DNA) within prostate tissues. To analyze the role of gene expression in subsequent generations after initial thiacloprid exposure, the authors exposed pregnant outbred Swiss mice to the insecticide in order to assess the offspring for multiple generations. As a result, the researchers from the Université de Rennes in France state, “Our study revealed that exposure to thiacloprid induces [cell] proliferation and is associated with epigenetic alterations in the sperm of genes important for prostate development.” Increased cell proliferation in the prostate can cause the development of conditions such as benign prostatic hyperplasia (BPH) and prostatic intraepithelial neoplasia (PIN), and lead to prostate cancer. The study also finds elevated levels of specific biomarkers within the prostates of both the first and third generations, including phosphorylated histone H3, a marker crucial for cell division. Hox gene expression in both generations was also impacted, which plays a role in prostate development, based on the altered DNA methylation (abnormal changes) in the sperm of the analyzed mice. “In this study, we […]

(Beyond Pesticides, April 3, 2026) A literature review published in Chemico-Biological Interactions links pyrethroid insecticide exposure to cardiac dysfunction. Through a systematic review and meta-analysis of previous research through July 2025, the authors find emerging evidence that indicates pyrethroids induce adverse cardiovascular effects through pathways of inflammation, oxidative stress, and myocardial injury (damage to the heart muscle). “The meta-analytic findings of this study offer the first comprehensive overview of the cardiotoxic effects of pyrethroids, encompassing electrophysiological, biochemical, inflammatory, and redox disturbances,” the researchers state. “Together, these findings indicate that pyrethroids disrupt cardiac electrical stability and induce cytotoxic [killing or damaging cells], inflammatory, and oxidative damage.” Study Importance Scientific literature connecting various classes of pesticides to adverse health effects continues to mount, with synthetic pyrethroids emerging as a class of increasing concern. Due to their broad spectrum of activity, pyrethroids are extensively used in agriculture and land management but can persist in the environment and can cause neurotoxicity, endocrine disruption, reproductive dysfunction, and cardiovascular health implications. (See here and here.) In particular, pyrethroid exposure is associated with increased risks of developing cardiovascular disease. (See studies here, here, here, and here.) “Cardiac electrical activity is regulated by mechanisms that are highly sensitive […]

(Beyond Pesticides, April 1, 2026) Researchers at the University of Washington and members of the Washington State Liquor and Cannabis Board published a commentary piece in Clinical Therapeutics highlighting the growing inadequacy of state-level regulatory safeguards for pesticide contamination of cannabis products. The Environmental Protection Agency (EPA) is unable to assess pesticide residues, nor is it permitted to set tolerance limits under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), because, according to the Controlled Substances Act (CSA), cannabis is a Schedule 1 narcotic, meaning there is “no accepted medical use.” As a result, EPA cannot conduct a full assessment of pesticide exposure associated with inhalation, ingestion, and dermal (skin) adsorption. There is an ongoing rescheduling process that was proposed in 2024 and followed up with an executive order in late 2025 to transition cannabis toward Schedule III status, suggesting that there would be an opening for EPA to promulgate rulemaking to support state-level regulations if it were to move forward. An analysis of active legislation in state legislatures for the 2026 session highlights the concerns—at least 14 states (including Connecticut, California, Georgia, Hawai’i, Illinois, Iowa, Kansas, Kentucky, Maine, New Hampshire, Oklahoma, Virginia, West Virginia, and Wisconsin) had bills to […]

(Beyond Pesticides, March 31, 2026) A statement decrying chemical company secrecy was released today by over 200 grassroots, health, farm, farmworker, environmental, and consumer groups, socially responsible corporations, over 340 citizens from 46 states, and international partners. The statement, released before the U.S. Supreme Court tomorrow reaches the final deadline for submission of amicus briefs in a case in which Bayer/Monsanto argues, with support of the Trump administration, that it should not be required to disclose on its product labels the potential hazards of its pesticide products. Oral arguments in the case will be heard on April 27, with a decision anticipated in June. Decades of law have upheld the legal argument that chemical companies are liable for their failure to warn users of their pesticides about the harm that they could cause. Bayer/Monsanto is attempting to reverse years of case law and billions of dollars in jury verdicts and future cases in which the company has been held liable for causing cancer but not warning product users. See statement, Stop Chemical Company Secrecy of Pesticide Product Hazards. Chemical Industry State Campaign The chemical industry last year launched a multi-pronged campaign to establish immunity from litigation by those who have […]

(Beyond Pesticides, March 30, 2026) Through today, organizations, institutions, and corporations can sign on to a public statement calling for chemical companies to continue to be held liable for harming but not warning people who use their pesticide products. The statement, joined by grassroots, health, farm, farmworker, environmental and consumer groups, and socially responsible corporations, will be released tomorrow—just as U.S. Supreme Court begins on April 1 considering Monsanto/Bayer’s claim that the company is not responsible for failing to warn those whose cancer was found by a jury trial to be caused by its weed killer glyphosate (RoundupTM). Groups can sign on to the statement by 5:00pm (Eastern) by clicking here. In the case before the U.S. Supreme Court case, Monsanto v. Durnell, Monsanto/Bayer is seeking to overturn over $10 billion in jury verdicts and settlements and stop future litigation on their failure to warn about the potential cancer effects of glyphosate/RoundupTM. If Monsanto/Bayer wins, chemical companies will be able to legally withhold information on their pesticide product hazards not required to be disclosed by the U.S. Environmental Protection Agency (EPA).  Bayer/Monsanto wants to overturn decades of legal precedent, including a previous Supreme Court decision, which establishes EPA-required, minimum pesticide product label language, […]

(Beyond Pesticides, March 27, 2026) In a study of birth outcomes in Arizona, published in the Journal of Exposure Science & Environmental Epidemiology, researchers find that preconception and prenatal exposure to certain carbamates, organophosphates, and pyrethroids increases the risk of lower Apgar scores, a metric used to assess neonatal health at one minute and five minutes after birth. The results reveal that exposure to “several pesticide active ingredients at any point during preconception and/or pregnancy were associated with increased odds of low Apgar scores: the carbamates carbaryl and formetanate hydrochloride; the organophosphates diazinon and tribufos; and the pyrethroid cypermethrin.” This multi-institutional study, led by the University of Arizona with researchers from Harvard Chan School of Public Health and UCLA Fielding School of Public Health, provides novel insights, as it incorporates pesticide exposure over a 15-year period both before conception and throughout pregnancy. “To analyze associations of preconception and prenatal exposures to carbamate, organophosphate, and pyrethroid pesticide classes and 25 individual active ingredients with newborn Apgar scores to evaluate the relationship between these exposures and neonatal health,” the authors explain. They continue: “We used pesticide use registry and birth certificate data from 2006 to 2020, linked as part of the Arizona […]

(Beyond Pesticides, March 26, 2026) A review of pesticide exposure from a family member working in agriculture (“take-home” residues) finds that pesticide levels in the home are elevated between 2.6- and 3.7-times. This and other nonoccupational exposure data from homes are drawn from the Agricultural Health Study (AHS), a National Cancer Institute (NCI) and National Institute of Environmental Health Sciences (NIEHS) prospective study of cancer and other health outcomes in a cohort of licensed pesticide applicators and their spouses from Iowa and North Carolina. Between 1993 and 1997, with follow-up between 1999 and 2021, AHS tracks occupational and nonoccupational exposure and subsequent health effects from pesticide exposure. The current study, published in Environmental Advances, reexamines a quantitative analysis on nontarget, “active-ingredient-specific” exposure to pesticides from multiple pathways—applying new criteria to AHS spousal exposure to the insecticide chlorpyrifos and the herbicide atrazine. The three pesticide exposure pathways include take-home, agricultural drift, and residential use. Building on a 2019 study, researchers consider data from additional studies published between 2019 and 2024, “providing support that all three pathways contribute to pesticide exposure.” More importantly, the updated estimates of nontarget exposure to chlorpyrifos and atrazine are overall strengthened by the incorporation of new data, highlighting the […]

(Beyond Pesticides, March 25, 2026) A literature review, published in Diseases, showcases the wide body of scientific literature linking pesticide exposure to liver disease through both apoptotic (programmed cell death without triggering inflammation) and non-apoptotic (regulated cell death with an inflammatory response) pathways. “In summary, our study confirms that pesticides carry significant health risks and sheds light on the underreported mechanisms that can drive their overall toxicity as a whole and hepatotoxicity [liver] in particular,” the researchers state.  In addition to analyzing the science on pesticide-induced apoptosis, the researchers “systematically illustrated an underappreciated mechanism of pesticide-induced overall and hepatic toxicity, i.e., the ability to induce non-apoptotic regulated cell death (RCD) pathways such as ferroptosis, necroptosis, and pyroptosis.” They continue, saying, “Importantly, our review stresses the contribution of pesticide-induced cell death modes to inflammation and immunity regulation in hepatic pathology.” Background Pesticides, as a comprehensive group, can be subdivided into classes based on their targets: rodenticides (rodents), herbicides (weeds), insecticides (insects), fungicides (fungi), nematicides (nematodes), acaricides (mites and ticks), and bactericides (bacteria). The use of these pesticides, particularly in agriculture, has skyrocketed over recent decades. As the authors state: “In 2019, the total pesticide market size was estimated to approach $85 […]

(Beyond Pesticides, March 12, 2026) The science connecting pesticide exposure to neurotoxicity continues to mount. A study in Discover Toxicology highlights neurotoxic pollutants as significant environmental threats, showcasing the adverse impacts on vertebrates’ neurological health from pesticides, including organophosphates, carbamates, and organochlorines. “These substances disrupt normal neurophysiological functions by impairing neurotransmission, generating oxidative stress, provoking neuroinflammation, and initiating neuronal cell death,” the authors say. They continue, “Such disturbances are linked to cognitive deficits, motor impairments, and abnormal neural development.” Neurological conditions can manifest as headaches, muscle weakness, tremors, paralysis, coordination challenges, vision loss, hallucinations, vertigo, seizures, memory loss, slurred speech, trouble breathing with minimal exertion, and more. The range of adverse effects from low-dose, long-term exposure and low-dose (or subchronic) exposure during developmental phases of life raises serious questions about the adequacy of the regulatory review of pesticides, which focuses on acute high and lethal dose exposure. One study on the neurotoxicity of pesticides, published in Chemosphere, concludes, “New regulatory and preventive measures to mitigate the neurotoxic effects of pesticides are needed.” (See also Daily News.) Even at low concentration, chronic exposure to pesticides and other environmental contaminants “poses serious ecological and health concerns” that occur as these chemicals “bioaccumulate […]

(Beyond Pesticides, March 6, 2026) The Farm Bill—the Farm, Food, and National Security Act of 2026, H.R. 7567—reported out of the Agriculture Committee in the U.S. House of Representatives yesterday strips environmental and public health protections from pesticides, reversing over 90 years of environmental laws adopted by Congress to protect farmers, consumers, and the environment that stretch back to the first Farm Bill in 1933. The Committee rejected the Protect Our Health Amendment, sponsored by Rep. Chellie Pingree (D-ME), which would have ensured that the final bill maintain three core safeguards in current law: (i) Judicial review of chemical manufacturers‘ failure to warn about pesticide hazards; (ii) Democratic right of local governments in coordination with states to protect residents from pesticide use; and, (iii) Local site-specific action to ensure protection—the safety of air, water, and land from pesticides under numerous environmental statutes. All Republicans and one Democrat (Rep. Adam Gray, D-CA) on the Committee blocked the Pingree amendment. The Agriculture Committee bill adversely affects a wide range of social and conservation issues, including the protection of family farms, food security, environmental and public health, local and state authority, and judicial review, according to a cross-section of groups representing these interests. […]

(Beyond Pesticides, March 4, 2026) In the International Journal of Epidemiology, researchers from France assess the risks of kidney cancer with a wide range of agricultural activities and tasks, finding that occupational exposure heightens kidney cancer risk. In studying participants from the French AGRIculture and CANcer cohort (AGRICAN) with incident kidney cancer, elevated risks of disease development between 25-56% are documented for both men and women engaging in agricultural activities. In men, the authors find increased kidney cancer in those “working with rapeseed and sunflowers, and tasks related to other crops such as corn, wheat/barley, beet, and tobacco.” In women, an increased risk is noted for winegrowers and corn growers. “Pesticide use (on fields and/or seeds) was associated, for both sexes, with these crops, showing exposure-response relationships with crop area and work duration,” the researchers state. This study, of a large cohort of agricultural workers, highlights the disproportionate risks of adverse kidney health to farmworkers directly handling pesticides or encountering pesticide residues on recently treated products. According to the World Cancer Research Fund, kidney cancer is the 14th most common cancer worldwide, affecting men more often than women. Kidney cancer incidence and mortality have increased globally, with various causes, such […]

(Beyond Pesticides, March 3, 2026) Research published in Critical Reviews in Toxicology (CRT) and Proceedings of the National Academy of Sciences (PNAS) documents the genetic and epigenetic (changes to gene function without altering the DNA sequence) effects to pesticide-exposed groups through early-life exposure and from transgenerational inheritance (passed down through generations). These studies highlight the complex nature of mechanisms of toxicity, as well as the various pesticide exposure routes that begin even prior to conception. The analyses evaluate general and specific pesticide exposure as reported in observational and laboratory research. Through a systematic review and meta-analysis of studies on “DNA damage, cytogenetic damage, DNA methylation, or gene expression outcomes associated with prenatal and early childhood pesticide exposure,” the CRT authors link genotoxic mechanisms and epigenetic alterations to adverse health outcomes while the PNAS study shows pesticide-induced epigenetic alterations in mammals across 20 generations that “suggest the maternal and paternal lineages can both induce and inherit epigenetic alterations that influence disease (e.g., kidney, testis, ovary, prostate) incidence, reproductive health (e.g., parturition, infertility), and overall fitness generationally.” As the CRT study states: “One of the main ways pesticides can cause harm is through genotoxicity—their ability to damage genetic material. This damage can […]

(Beyond Pesticides, February 26, 2026) Published in PLOS ONE, research in Brazil “analyzed the impact of occupational/household chronic exposure to pesticides on the clinicopathological profile of breast cancer in rural women from Paraná southwest, a predominantly rural landscape with large pesticide uses,” finding that “pesticide exposure favors the occurrence of more aggressive breast cancer.” The study highlights the disproportionate risks of pesticides to farmworkers, focusing on women, as it compares exposed and unexposed populations and breast cancer tumor/disease characteristics. One of the study authors, Carolina Panis, PhD, discussed her earlier research at the Beyond Pesticides’ 42nd National Forum Series, The Pesticide Threat to Environmental Health: Advancing Holistic Solutions Aligned with Nature. In her previous work, Pesticide exposure and increased breast cancer risk in women population studies, Dr. Panis documents a number of pesticides that “can increase the risk of BC [breast cancer] development through various mutagenic [genetic mutations] and nonmutagenic mechanisms and can act directly as carcinogens or indirectly as biochemical modifiers and hormonal deregulators. The underlying mechanisms include endocrine disruption; genotoxicity; epigenetic changes [changes to gene function without changing DNA]; enhanced cell migration, invasion, and…” more. Dr. Panis and other researchers at the Forum support community-level understanding of the […]

(Beyond Pesticides. February 24, 2026) Leukemia is the leading contributor to the clear rise in childhood cancer cases over the last few decades, and the general association of pesticide exposures with childhood leukemia is firmly established. Now, a new study is the first to assess the effect of pesticide exposures on the survival of children with leukemia. The study found a statistically significant link between residential rodenticide exposure and a higher risk in children of death from acute lymphoblastic leukemia (ALL), with about 10% of the exposed children dying within five years of diagnosis. Crucially, pre- and post-natal periods were the most critical exposure windows—and the intervals when residents were most likely to use rodenticides. With proper treatment, about 80% of children diagnosed after age one with ALL can survive. The study, by University of California, Berkeley epidemiologist Seema Desai and colleagues at several other California state universities, used data from the California Childhood Leukemia Study (CCLS), an ongoing population-based case-control study identifying genetic and environmental risks for the range of leukemias occurring in children. Beyond Pesticides covered a 2009 study using the CCLS that found elevated risk of ALL in children living near agricultural pesticide applications, along with a […]

(Beyond Pesticides, February 18, 2026) Research finds that widespread agricultural pesticide use increases chronic dietary exposure in poultry and leads to adverse reproductive effects, despite meeting legal residue limits. As published in Poultry Science by researchers in Poland, the study analyzes low-dose exposure of roosters (Gallus gallus domesticus) to the fungicide tebuconazole (TEB), the insecticide imidacloprid (IMI), and the weed killer glyphosate (GLP) individually and in mixtures, with all concentrations at or below the maximum residue limits (MRLs) established by the European Union (EU). “Sub-MRL pesticide exposure impaired male reproductive function, with the most pronounced effects observed following combined treatments,” the authors report. They continue: “[E]xposure resulted in reduced semen quality, decreased fertility and hatchability, and increased embryo mortality, particularly in groups receiving IMI alone or in combination. These functional impairments were accompanied by detectable pesticide residues in reproductive tissues and body fluids, as well as modulation [modification/alteration] of local and systemic immune parameters.” The results of the experiment highlight how combined pesticide exposure, resulting from common use of multiple pesticide active ingredients concurrently, produces “stronger and more persistent reproductive effects than individual compounds, indicating mixture-specific toxicity.” This study is particularly important, as it represents the chronic exposure to MRL-compliant […]

(Beyond Pesticides, February 11, 2026) The first U.S. jury trial on the weed killer paraquat against global chemical companies Syngenta Crop Protection, Chevron U.S.A., FMC Corporation, and their predecessors was scuttled last month due to a settlement on the eve of the case being heard in court. Settlements are commonly used by pesticide manufacturers seeking to avoid public disclosure of internal documents on chemical hazards and wrongdoing that could result from a public trial. In Mertens et al. v. Syngenta, Chevron, and FMC, the six plaintiffs suing three corporations allege that exposure to paraquat-based herbicide products contributed to their Parkinson’s Disease diagnosis. While the terms of the settlement have not yet been disclosed, Lawsuit Information Center states that the paraquat class action multidistrict litigation (MDL) includes 8,257 cases as of January 16, 2026. In 2021, multiple cases were settled for more than $187 million. Background on Mertens Complaint In their complaint, the plaintiffs point to five causes of action, including “strict products liability design defect” (Count 1), “strict products liability failure to warn” (Count 2), negligence (Count 3), breach of implied warranty of merchantability (Count 4), and punitive damages (Count 5). Count 1—Strict Products Liability Design Defect: In the first […]

[Update on February 9, 2026: In a press release on Friday, February 6, titled “EPA Implements Strongest Protections in Agency History for Over-the-Top Dicamba Use on Cotton and Soybeans for Next Two Growing Seasons,” the U.S. Environmental Protection Agency (EPA) continues to ignore the wide body of science that documents harms from dicamba, as well as the viability of alternative methods, in establishing what the agency is boasting are “the strongest protections in agency history for over-the-top (OTT) dicamba application on dicamba-tolerant cotton and soybean crops” as a direct response to the “strong advocacy of America’s cotton and soybean farmers.” These so-called “strong protections” are described as a way to ensure farmers can access the tools they “need” while also protecting the environment from dicamba’s harmful drift. In using “gold-standard science and radical transparency,” EPA created new label restrictions for the next two growing seasons that include “cutting the amount of dicamba that can be used annually in half, doubling required safety agents, requiring conservation practices to protect endangered species, and restricting applications during high temperatures when exposure and volatility risks increase.” Relying on unenforceable label restrictions and mitigation measures, however, fails to adequately protect health and the environment. See […]

(Beyond Pesticides, February 4, 2026) Using data from the Agricultural Health Study (AHS) database launched in 1993 by the National Cancer Institute and the National Institute of Environmental Health Sciences, research study results “show greater diabetes risk“ from exposure to organochlorine, organophosphate, and carbamate insecticides, phenoxy and other herbicides, and the fumigant carbon tetrachloride/disulfide exposure. The study, published in Environment International, evaluated nearly 4,000 diabetes cases drawn from AHS follow-up surveys between 1999 and 2021. Results Researchers found evidence of an association between 18 pesticide active ingredients and diabetes. These included two phenoxy herbicides, 2,4,5-T and 2,4,5-TP, and seven organochlorine insecticides (DDT, aldrin, dieldrin, chlordane, heptachlor, toxaphene, and lindane). While all these organochlorine pesticides are banned for use in the U.S. (with the exception of pharmaceutical uses of lindane), legacy residues of the chemicals and/or their metabolites continue show up in the environment, food, and the human body, and 2,4,5-T and its TCDD dioxin contaminant has multigenerational effects. There was exposure risks among other pesticides were identified as well, including: 3 organophosphate insecticides (diazinon, malathion, and phorate); 2 carbamate insecticides (carbofuran and carbaryl); 3 other herbicides (butylate, metribuzin, and chlorimuron ethyl); and the fumigant carbon tetrachloride/disulfide. The median age of […]

(Beyond Pesticides, January 29, 2026) A study of ecotoxicity risk from neonicotinoid insecticides, published in Environmental Chemistry and Ecotoxicology, finds that chemicals in this class of pesticides, particularly dinotefuron, increase the body temperature of Apis mellifera (European honey bee) and subsequently accelerate the translocation (movement) of contaminants into hives by the honey bees. The research indicates that neonicotinoids affect acetylcholine receptors in the nervous system, leading to an “elevation in octopamine titer [neurotransmitter/hormone] and subsequent increase in the body temperature of honeybees,” the authors report. They continue: “Furthermore, we observed a considerable upregulation [of] the expression of a flight gene flightin in honeybees. This gene accelerates the homing behavior of honeybees and facilitates the rapid and frequent transport of neonicotinoid pesticide-contaminated nectar to the hive.” In describing their results, the researchers state: “For the first time, we propose that neonicotinoid pesticides accelerate the homing ability of honeybees by affecting their body temperature, which leads to more neonicotinoid pesticides entering the hive and explains the prevalence of neonicotinoids and at higher concentrations in terms of their effects on the honeybee body temperature that enhances homing.” This accelerated movement of neonicotinoid pesticides into honey bee hives heightens the toxicity risks to honey […]

(Beyond Pesticides, January 27, 2026) A three-part study published in Molecular Neurodegeneration draws a connection between Parkinson’s disease (PD) and the organophosphate chlorpyrifos. “Since chlorpyrifos (CPF) exposure has been implicated as a risk factor for PD, we investigated its association to incident PD and if this association is biologically plausible using human, rodent, and zebrafish (ZF) studies,” the researchers state. Together, the three experiments “strongly implicate exposure to CPF as a risk factor for developing PD,” as the authors find that exposure, even at very low concentrations, causes selective toxicity to dopaminergic neurons that are critical for functions of movement, cognition, emotion, and more. The results reveal that in humans, long-term residential exposure is associated with more than a 2.5-fold increased risk of developing PD, while exposure in mice causes “motor impairment, dopaminergic neuron loss, microglial activation, and an increase in pathological α-synuclein (α-syn) [proteins primarily found in the brain].” The researchers continue, “Using ZF, we found that CPF-induced dopaminergic neuron loss was at least partially due to autophagy dysfunction and synuclein accumulation, as knocking down LC3 [a protein chain] recapitulated the dopaminergic neuron loss.” These three studies highlight the association of CPF with increased risks for developing PD, as […]

(Beyond Pesticides, January 22, 2026) Published in Environmental Research, a review of experimental studies by George Mason University researchers regarding reproductive toxicity of neonicotinoid pesticides (neonics) in rodents finds that all studies “demonstrated negative impacts on male reproductive endpoints in association with neonic exposure, including reduced sperm count, reduced sperm motility, and altered sperm morphology.” These studies highlight how neonics, designed to target insect nervous systems, can affect mammalian systems, representing risks to human health. Criteria for inclusion in the review was restricted to endocrine and/or reproductive outcomes in male rats and mice, leading the authors to analyze 21 studies published between 2005 and 2025. “This narrative review employed a systematic approach and determined that neonics exhibit reproductive toxicity in male rats and mice, particularly impairing testicular function and sperm quality at high exposure levels,” the researchers report. They continue, “Despite species-specific differences, the conserved nature [core mechanism] of reproductive processes across mammals supports the relevance of these findings to human health.” Study Background Neonicotinoids are a class of insecticides that share a common mode of action that affects the central nervous system of insects, resulting in paralysis and death. There is a wide body of science on the effects […]