Daily News Archive
Pesticide Resistant Gene
Scientists from the University of Melbourne in Australia have raised concerns following their discovery of a single gene that gives vinegar flies resistance to a wide range of pesticides. The scientists are worried as this single mutation unexpectedly provides the fly (Drosophila sp) with resistance to a range of commonly available, but chemically unrelated, pesticides. Significant also, is this species is rarely targeted with pesticides and many of the chemicals it is resistant to, it has never been exposed to before.
Researchers at the University of Melbourne and the Centre for Environmental Stress and Adaptation Research (CESAR) that made the discovery believe the mutation arose in Drosophila soon after the introduction of DDT and has since spread throughout the world. The gene has also persisted rather than, as expected, disappearing as the use of DDT around the world declined.
The Drosophila resistance gene, named Cyp6g1, is part of a large family of genes called the Cytochrome P450 genes that are found in many species, including humans. Previous studies have implicated some members of this P450 family in pesticide resistance. However, the function of the majority of the 90 Drosophila P450 genes is unknown. CESAR is now analyzing these genes to determine their function in Drosophila and in the pest insects, the cotton bollworm (Helicoverpa armigera) and the sheep blowfly responsible for flystrike (Lucilia cuprina).
In the Drosophila,
Cyp6g1 confers resistance by producing up to 100 times more than the
normal level of protein that breaks down DDT and other pesticides. Given
the number of P450 genes present in Drosophila, it was unexpected that
a single version of one gene could be associated with such widespread
"Our research, so far, does not unequivocally demonstrate that Cyp6g1 is the sole culprit for this resistance, but the current evidence leaves little doubt that about its central role," says University of Melbourne geneticist, Dr Phil Batterham, and Program Leader for the Chemical Stress Program within CESAR, a special research centre that includes researchers from the Universities of Melbourne, La Trobe and Monash.
Species will normally
lose mutations that protected it against a particular pesticide once
that pesticide ceases to be used. This is because, in the absence of
the pesticide, the mutation suddenly confers a disadvantage. In this
"This highlights more than ever that what we do today to control pests could irreversibly change the gene pool of that species," says Batterham. "Researchers investigating pesticide resistance sometimes fails to take sufficient notice of research into Drosophila. It maybe a model genetic organism, but it is still an insect and things that happen to Drosophila happen to other insects," he warns. "This research showed how easy it is for a single mutation to have such a diverse impact. A similar mutation in a pest species could have devastating consequences," he says.
The research is published in the latest edition of the journal Science. (Daborn, P.J., et al. "A Single P450 Allele Associated with Insecticide Resistance in Drosophila." Science 297(5590): 2253-2256.)
For more information contact, Dr Phil Batterham, University of Melbourne Department of Genetics at [email protected].