is selective, postemergent herbicide used for annual and perennial grass
weeds in turfgrass, including sod farms, commercial and residential turfs,
and ornamental. It is found in such herbicides as Acclaim®, Puma®, and
has an oral LD50 of 2,357 mg/kg for rats, an inhalation LC50 >0.511
mg/L for rats, and acute dermal toxicity of >2,000 mg/kg for rats and
>1,000 mg/kg for rabbits. It is considered a slight skin irritant, and
an extreme eye irritant, with non-reversible corneal opacity in rabbits at
21 days. It is not a dermal
sensitizer (EPA, 1998). Primary routes of exposure would be through skin
absorption, vapor and mist inhalation. It is harmful if inhaled or ingested (MSDS, Acclaim).
a chronic toxicity feeding study on beagle dogs, the NOEL (No Observable
Effect Level) was 0.375 mg/kg/day and the LOEL (Lowest Observed Effect
Level) was 1.875 mg/kg/day based on decreases in body weight gain. In a
carcinogenicity study on mice, there was evidence of carcinogenicity at
the highest dose tested (EPA, 1998). Fenoxaprop-ethyl is classified as a
possible human carcinogen, with limited human evidence and inadequate
animal evidence (MSDS, Acclaim). In oral developmental toxicity studies of
rats, the NOEL was 32 mg/kg/day and the LOEL was 100 mg/kg/day, based on
increased malformations, reduced fetal body weights, reduced placental
weights, and retarded skeletal ossification of the cranium, sternebrae and
5th metacarpals. A 2-generation reproductive toxicity study of
rats, the NOEL was 0.25 mg/kg/day and the LOEL was 1.5 mg/kg/day based on
reduced pup body weights (EPA, 1998). Fenoxaprop-ethyl is not thought to
be mutagenic or to effect fertility (MSDS, Acclaim).
is toxic to fish. Drift or runoff of this herbicide could adversely affect
nontarget plants. It should not be applied directly to water or areas
where surface water is present (MSDS, Acclaim).
EPA. 1998. Federal Register Document: Fenoxaprop-ethyl. April 2. Office of
Pesticide Programs. Washington, DC.
Material Safety Data Sheet (MSDS): Acclaim 1 EC Herbicide. AgrEvo. Wilmington, DE.