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Study Finds That Antibacterial Enhances Endocrine Disruption

(Beyond Pesticides, January 9, 2008) Triclocarban, an antibacterial compound widely used as an additive to a range of household and personal care products including bar soaps, detergents, body washes, cleansing lotions, and wipes, has been found to have an amplification effect on the activity of natural hormones, which in turn can lead to adverse reproductive and developmental effects.

In the study, published online November 29, 2007 in Endocrinology, researchers from University of California- Davis and Yale University investigated the endocrine disrupting properties of triclocarban and other polychlorinated diphenyl urea compounds by exposing human cells and rats to levels similar to those found in people. Triclocarban was found to have a synergistic interaction with the sex hormone, testosterone- present in both males and females. This interaction produced a positive, amplified biological effect, which is likely to hyperstimulate native sex hormones. This amplification of sex hormone activity occurs at the target cell and can result in developmental defects or decreased reproductive function. Researchers further explained that ovulation and ovarian function in females can be disrupted, while sperm quality can be decreased in males.

The researchers also point out that the results of their study create a new category for endocrine disruptive substances to include “hormone amplifiers or enhancers” rather than simple agonists or antagonists in order to accommodate the synergistic property demonstrated by triclocarban. They also note that since triclocarban has the potential to amplify synthetic compounds, further investigation into its interaction with oral contraceptives and hormone replacement therapy is needed.

Triclocarban, like its cousin triclosan, has been linked to numerous health and environmental effects. When disposed into residential drains and carried to streams and rivers, it kills beneficial organisms in soil and water. Both of these chemicals have been found in breast milk and fish. Triclocarban, along with triclosan, survives treatment at sewage plants and most ends up in waterways and sludge spread on agricultural fields, and may end up on produce. Researchers at the John’s Hopkins Bloomberg School of Public Health found that triclocarban was the fifth most frequent contaminant among 96 pharmaceuticals, personal care products and organic wastewater contaminants evaluated and that levels of triclocarban in water resources nationwide are much higher than previously thought.

In 2005, the U.S. Food and Drug Administration led a panel of experts and industry representatives to weigh and analyze different germ killing methods. The panel found “no firm scientific evidence that the flood of antimicrobial products we observe has any discernible benefit over the use of regular soap and water.”

TAKE ACTION: You can stay healthy and put pressure on manufacturers to phase out antibacterials by not using products with triclosan or triclocarban. Stay hygienic the most effective way, by using plain soap and water.

Source: Environmental Science and Technology


One Response to “Study Finds That Antibacterial Enhances Endocrine Disruption”

  1. 1
    Rev K L Maines Says:

    Greetings! Since the beginning of history, God has been revealing events to come to His people. On June 19, 2008 the Lord strongly impressed on me the need for His people to educate themselves concerning the products they buy and consume. I am writing this because I believe the Lord is warning His people of days to come. There are certain chemicals found in everyday products that are going to wreak havoc on our environment and well-being. One such chemical is Triclosan. Triclosan is an excellent product when used to protect healthcare providers treating patients with contagious diseases, such as medical professionals who are working in third-world countries during serious disease outbreaks. It can be a lifesaver to medical workers under those circumstances; however, the use of triclosan has not been tightly regulated, and it is now being overused in many products you and I use every day.

    The warning cry is that this chemical and similar compounds will end up killing us if we continue to misuse and overuse them. Overuse puts us all at risk at contracting antibiotic-resistant superbugs, and individually, triclosan-based products weaken our immune systems. Please do not use or purchase triclosan-based products.

    I hope you will take the time to read this brief message about the dangers of the chemical Triclosan and similar tricloson-like products (such as Triclocarban and quaternary ammonium compounds):

    *Triclosan is found in hundreds of common everyday products, including nearly half of all commercial soaps.

    *It is used so frequently that triclosan has made its way into the human body – a Swedish study found triclosan in human breast milk in three out of five women.

    *Numerous studies have found that triclosan promotes the emergence of bacteria that are resistant to antibiotics.

    *Dioxin, a highly carcinogenic, endocrine disrupting compound, may be formed during the manufacturing process of triclosan, and thus is a likely contaminant. More alarmingly, researchers found that when sunlight is shined on triclosan in water and on fabric, a portion of triclosan is transformed into dioxin. Because of its ubiquitous nature, the conversion to dioxin is of major concern.

    *Triclosan is one of the most frequently detected compounds in rivers, streams, and other bodies of water, often in high concentrations. Triclosan is highly toxic to a number of different types of algae. Since algae are the primary producers in many aquatic ecosystems, high levels of triclosan may have destructive effects on aquatic ecosystems.

    *The American Medical Association took an official stance against adding antimicrobials to consumer products in 2000 and has repeatedly urged the Food and Drug Administration (FDA) to better regulate these chemicals.
    For more information google.com: “Triclosan.”

    The single most important thing you can do in your life is to establish a personal relationship with Jesus, in which He is your personal Lord and Savior. If you have not yet accepted Jesus into your life, you can do so now, by praying this prayer:

    “Father, I know that I have broken your laws and my sins have separated me from you. I am truly sorry, and now I want to turn away from my past sinful life toward you. Please forgive me, and help me avoid sinning again. I believe that your son, Jesus is the Messiah and He died for my sins, was resurrected from the dead, is alive, and hears my prayer. I invite Jesus to become the Lord of my life, to rule and reign in my heart from this day forward. Please send your Holy Spirit to help me obey You, and to do Your will for the rest of my life. Amen.”

    Blessings to you,

    Rev. K. L. Maines

    Rev. K. L. Maines

    Duly Ordained Pastor/Evangelist

    For Prayer email me at : [email protected]

    References taken from the CDC website:http://www.cdc.gov/ncidod/eid/vol7no3_supp/levy.htm

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    2.Levy SB. The antibiotic paradox. How miracle drugs are destroying the miracle. New York: Plenum; 1992.

    3.McMurry LM, Oethinger M, Levy SB. Triclosan targets lipid synthesis. Nature 1998;394:531-2.

    4.McMurry LM, Oethinger M, Levy SB. Overexpression of marA, soxS or acrAB produces resistance to triclosan in Escherichia coli. FEMS Microbiol Lett 1998;166:305-9.

    5.Suller MT, Russell AD. Triclosan and antibiotic resistance in Staphylococcus aureus. J Antimicrob Chemother 2000;46:11-8.

    6.Hoang TT, Schweizer HP. Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in homoserine lactone synthesis. J Bacteriol 1999;181:5489-97.

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    8.Mereghetti L, Quentin R, Marquet-van der Mee N, Audurier A. Low sensitivity of Listeria monocytogenes to quaternary ammonium compounds. Appl Environ Microbiol 2000;66:5083-6. 9.*McMurry LM, McDermott PF, Levy SB. Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan. Antimicrob Agents Chemother 1999;43:711-3.

    10.*Heath RJ, Roch CO. A triclosan-resistant bacterial enzyme. Nature 2000;406:145-6.

    11.Radosti-Slater C, Aller GV, DeWolf W, Greenwood R, Nicholas R, Payne D, et al. Mode of action of triclosan in S. aureus [abstract]. American Society for Microbiology annual meeting, Los Angeles, California, 2000 May 21-24. Abstract 101, p. 26.

    12.Meade MJ, Callahan TM. Unique mechanism of triclosan resistance identified in environmental isolates [abstract]. American Society for Microbiology annual meeting, Los Angeles, California, 2000 May 21-24. Abstract 73, p. 19.

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    14.Alekshun MN, Levy SB. The mar regulon: multiple resistance to antibiotics and other toxic insults. Trends Microbiol 1999;7:410-3.

    15.Barbosa T, Levy SB. Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA. J Bacteriol 2000;182:3467-74.

    16.Chuanchuen R, Beinlich K, Schweizer HP. Multidrug efflux pumps and triclosan resistance in Pseudomonas aeruginosa [abstract]. American Society for Microbiology annual meeting, Los Angeles, California, 2000 May 21-24. Abstract 31, p. 8.

    17.Akimitsu N, Hamamoto H, Inoue R, Shoji M, Akamine A, Takemori K, et al. Increase in resistance of methicillin-resistant Staphylococcus aureus to beta-lactams caused by mutations conferring resistance to benzalkonium chloride, a disinfectant widely used in hospitals. Antimicrob Agents Chemother 1999;43:3042-3.

    18.*Strachan DP. Hay fever, hygiene, and household size. BMJ 1989;299:1259-60.

    19.*Braun-Fahrl*nder CH, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, et al. Prevalence of hay fever and allergic sensitization in farmer’s children and their peers living in the same rural community. Clin Exp Allergy 1999;29:28-34.

    20.*Rook GAW, Stanford JL. Give us this day our daily germs. Immunol Today 1998;19:113-6. 21.*Matricardi PM, Rosmini F, Riondino S, Fortini M, Ferrigno L, Rapicetta M, et al. Exposure to foodborne and orofecal microbes versus airbone viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 2000;320:412-7.

    22.*Aaby P, Shaheen SO, Heyes CB, Goudiaby A, Hall AJ, Shiell AW, et al. Early BCG vaccination and reduction in atopy in Guinea-Bissau. Clin Exp Allergy 2000;30:644-50.

    23.*Folkerts G, Walzl G, Openshaw PJM. Do common childhood infections “teach” the immune system not to be allergic? Immunol Today 2000;21:118-20. }

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